@article{oai:nagasaki-u.repo.nii.ac.jp:00011617,
 author = {Yamamoto-Fukuda, Tomomi and Takahashi, Haruo and Koji, Takehiko},
 issue = {1},
 journal = {International Journal of Pediatric Otorhinolaryngology},
 month = {Jan},
 note = {Objectives: To investigate the pathogenesis of one of the most troublesome conditions following ear surgery, a middle-ear cavity problem. Methods: Keratinocyte growth factor (KGF) and its receptor (KGFR), the ratio of proliferating epithelial cells using Ki-67, and the extent of infiltration of B cells and T cells were examined immunohistochemically in 10 ears with a cavity problem, 70 ears with cholesteatoma and 8 ears with normal skin at the retroauricular incision. Results: KGF was positive in 40% of cavity problem specimens, 37.5% of normal skin specimens, and was positive in 88% of cholesteatoma specimens (cavity problem vs. cholesteatoma, p = 0.0004). The positive rate of KGFR in the cavity problem group (33.3%) was between those in cholesteatoma (60%) and normal skin (0%). In contrast to the cholesteatoma specimens, a significantly smaller number of Ki-67 labeling index (LI) was detected in the cavity problem specimens. B cell LI was significantly higher but T cell LI was significantly lower in the cavity problem specimens than in the cholesteatoma group. Conclusions: Our present study indicated that the discordance of paracrine action between stromal KGF and epithelial KGFR with a large number of infiltrating B cells may play an important role in the pathogenesis of a cavity problem., International Journal of Pediatric Otorhinolaryngology, 76(1), pp.76-81; 2012},
 pages = {76--81},
 title = {Expression of keratinocyte growth factor (KGF) and its receptor in a middle-ear cavity problem},
 volume = {76},
 year = {2012}
}