{"created":"2023-05-15T16:38:06.266928+00:00","id":11617,"links":{},"metadata":{"_buckets":{"deposit":"d9c6ceae-594c-4115-9e15-9176d1d88f18"},"_deposit":{"created_by":2,"id":"11617","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"11617"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00011617","sets":["29:30"]},"author_link":["44344","44343","44342"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"81","bibliographicPageStart":"76","bibliographicVolumeNumber":"76","bibliographic_titles":[{"bibliographic_title":"International Journal of Pediatric Otorhinolaryngology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: To investigate the pathogenesis of one of the most troublesome conditions following ear surgery, a middle-ear cavity problem. Methods: Keratinocyte growth factor (KGF) and its receptor (KGFR), the ratio of proliferating epithelial cells using Ki-67, and the extent of infiltration of B cells and T cells were examined immunohistochemically in 10 ears with a cavity problem, 70 ears with cholesteatoma and 8 ears with normal skin at the retroauricular incision. Results: KGF was positive in 40% of cavity problem specimens, 37.5% of normal skin specimens, and was positive in 88% of cholesteatoma specimens (cavity problem vs. cholesteatoma, p = 0.0004). The positive rate of KGFR in the cavity problem group (33.3%) was between those in cholesteatoma (60%) and normal skin (0%). In contrast to the cholesteatoma specimens, a significantly smaller number of Ki-67 labeling index (LI) was detected in the cavity problem specimens. B cell LI was significantly higher but T cell LI was significantly lower in the cavity problem specimens than in the cholesteatoma group. Conclusions: Our present study indicated that the discordance of paracrine action between stromal KGF and epithelial KGFR with a large number of infiltrating B cells may play an important role in the pathogenesis of a cavity problem.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"International Journal of Pediatric Otorhinolaryngology, 76(1), pp.76-81; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier BV"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ijporl.2011.10.003","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2011 Elsevier Ireland Ltd. All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00234233","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01655876","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamamoto-Fukuda, Tomomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Haruo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koji, Takehiko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"IJPO76_76.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"IJPO76_76.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/11617/files/IJPO76_76.pdf"},"version_id":"a3bc21c7-3c6c-4408-bd70-992120307df7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"B cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Cavity problem","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"Keratinocyte growth factor (KGF)","subitem_subject_scheme":"Other"},{"subitem_subject":"KGF receptor (KGFR)","subitem_subject_scheme":"Other"},{"subitem_subject":"Ki-67","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of keratinocyte growth factor (KGF) and its receptor in a middle-ear cavity problem","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of keratinocyte growth factor (KGF) and its receptor in a middle-ear cavity problem"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-03-06"},"publish_date":"2012-03-06","publish_status":"0","recid":"11617","relation_version_is_last":true,"title":["Expression of keratinocyte growth factor (KGF) and its receptor in a middle-ear cavity problem"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:09:44.962425+00:00"}