@article{oai:nagasaki-u.repo.nii.ac.jp:00012264,
 author = {Kurosaki, Tomoaki and Higuchi, Norihide and Kawakami, Shigeru and Higuchi, Yuriko and Nakamura, Tadahiro and Kitahara, Takashi and Hashida, Mitsuru and Sasaki, Hitoshi},
 issue = {2},
 journal = {Gene},
 month = {Jan},
 note = {We have developed a novel vector constructed with pDNA, polyethylenimine (PEI), and mucin 1 (MUC1) aptamer for tumor-targeted gene delivery. The MUC1 aptamer and non-specific aptamer were employed to coat the pDNA/PEI complexes electrostatically and stable nanoparticles were formed. The addition of a non-specific aptamer to the pDNA/PEI complex decreased gene expression in the human lung cancer cell line, A549 cells expressing MUC1 regularly. At the same time, the pDNA/PEI/MUC1 aptamer complex showed higher gene expression than pDNA/PEI/non-specific aptamer complex. Furthermore, the pDNA/PEI/MUC1 aptamer complex showed markedly high gene expression in tumor-bearing mice; thus, pDNA/PEI/MUC1 aptamer complexes are useful as a tumor-targeted gene delivery system with high transfection efficiency., Gene, 491(2), pp.205-209; 2012},
 pages = {205--209},
 title = {Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer.},
 volume = {491},
 year = {2012}
}