{"created":"2023-05-15T16:38:34.856196+00:00","id":12281,"links":{},"metadata":{"_buckets":{"deposit":"fea7925c-2354-4535-8832-59814e7b78ea"},"_deposit":{"created_by":2,"id":"12281","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"12281"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00012281","sets":["73:74"]},"author_link":["45834","45839","45837","45835","45838","45836"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-07-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"236","bibliographicPageStart":"230","bibliographicVolumeNumber":"85","bibliographic_titles":[{"bibliographic_title":"Talanta"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Vitamin K is a fat-soluble vitamin involved in blood coagulation and bone metabolism. The detection and monitoring of vitamin K homologues in rheumatoid arthritis (RA) patients is a challenging problem due to the smaller concentrations of vitamin K and the presence of several interfering medications. Therefore, this study aimed to develop a new highly sensitive and selective chemiluminescence (CL) method designated to quantify vitamin K homologues in plasma of RA patients including phylloquinone (PK, vitamin K(1)), menaquinone-4 (MK-4, vitamin K(2)) and menaquinone-7 (MK-7, vitamin K(2)). The method was based on the unique photochemical properties of vitamin K homologues that were exploited for selective luminol CL reaction. The correlation coefficients of 0.998 or more were obtained in the concentration ranges of 0.1-100 ng mL(-1) vitamin K homologues. The detection limits were 0.03-0.1 ng mL(-1) in human plasma for vitamin K homologues. The developed HPLC-CL system was successfully applied for selective determination of vitamin K homologues in plasma of RA patients. The developed method may provide a useful tool for monitoring vitamin K homologues in different clinical studies such as RA, osteoporosis and hepatocellular carcinoma in which vitamin K is intervented.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Talanta, 85(1), pp.230-236; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier BV"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"21645693","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.talanta.2011.03.059","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2011 Elsevier B.V. All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00856594","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00399140","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"18733573","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ahmed, Sameh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kishikawa, Naoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohyama, Kaname"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imazato, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueki, Yukitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuroda, Naotaka"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"Talanta85_230.pdf","filesize":[{"value":"351.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Talanta85_230.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/12281/files/Talanta85_230.pdf"},"version_id":"2c6b9150-b2e0-48be-ada4-d764a7afe1f8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Luminol chemiluminescence","subitem_subject_scheme":"Other"},{"subitem_subject":"Photo-induced","subitem_subject_scheme":"Other"},{"subitem_subject":"Reactive oxygen species","subitem_subject_scheme":"Other"},{"subitem_subject":"Rheumatoid arthritis","subitem_subject_scheme":"Other"},{"subitem_subject":"Vitamin K homologues","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Selective chemiluminescence method for monitoring of vitamin K homologues in rheumatoid arthritis patients.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Selective chemiluminescence method for monitoring of vitamin K homologues in rheumatoid arthritis patients."}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-11-16"},"publish_date":"2011-11-16","publish_status":"0","recid":"12281","relation_version_is_last":true,"title":["Selective chemiluminescence method for monitoring of vitamin K homologues in rheumatoid arthritis patients."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:59:54.943096+00:00"}