{"created":"2023-05-15T16:30:13.377278+00:00","id":1273,"links":{},"metadata":{"_buckets":{"deposit":"4a698d88-3784-4013-8e1b-0d413ed63197"},"_deposit":{"created_by":2,"id":"1273","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1273"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001273","sets":["8:9"]},"author_link":["5902","5903","5907","5906","5908","5910","5905","5904","5909"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"3273","bibliographicPageStart":"3267","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"Oncology Letters"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Exosomal microRNAs (miRNAs) have been investigated as potential novel biomarkers, and miR-122 and miR-21 were shown to be important in hepatocellular carcinoma (HCC). We analyzed the importance of serum exosomal miRNA expression levels in HCC patients that underwent transarterial chemoembolization (TACE). Seventy-five HCC patients who underwent TACE as the initial treatment in Nagasaki University Hospital were enrolled. Exosomal miRNAs were isolated from serum samples collected before and after TACE. Exosomal miR-122 expression levels significantly decreased after TACE (P=0.012), while the exosomal miR-21 expression levels did not significantly change. The expression levels of exosomal miR-122 before TACE were shown to correlate significantly with aspartate aminotransferase (r=0.31, P=0.004) and alanine aminotransferase (r=0.33, P=0.003) levels, tumor diameter (r=0.29, P=0.010) and Child-Pugh score (r=-0.28, P=0.013). The median survival time for all patients was 47 months, and neither of the investigated exosomal miRNAs were shown to be independent factors associated with the disease-specific survival. According to the median relative expression of miR-122 after TACE/before TACE (miR-122 ratio) in liver cirrhosis patients (n=57), the patients with a higher miR-122 ratio had significantly longer disease-specific survival, compared with that of the patients with the lower miR-122 ratio (P=0.0461). Multivariate Cox proportional hazards regression analysis of clinical parameters revealed that a lower exosomal miR-122 ratio (HR 2.720; 95% confidence interval, 1.035-8.022; P=0.042) is associated with the disease-specific survival. Taken together, our results demonstrate that the exosomal miR-122 level alterations may represent a predictive biomarker in HCC patients with liver cirrhosis treated with TACE.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Oncology Letters, 16(3), pp.3267-3273; 2018　","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/ol.2018.8991","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2018, Spandidos Publications. All rights reserved."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"17921074","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"17921082","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suehiro, Tomoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyaaki, Hisamitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanda, Yasuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibata, Hidetaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honda, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ozawa, Eisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miuma, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taura, Naota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Kazuhiko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"OncLet16_3267.pdf","filesize":[{"value":"831.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"OncLet16_3267.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1273/files/OncLet16_3267.pdf"},"version_id":"4c58900e-261a-4c85-b931-2286a07b48c1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Chemoembolization, Exosome","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatocellular","subitem_subject_scheme":"Other"},{"subitem_subject":"MicroRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"Therapeutic","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Serum exosomal microRNA?122 and microRNA?21 as predictive biomarkers in transarterial chemoembolization?treated hepatocellular carcinoma patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Serum exosomal microRNA?122 and microRNA?21 as predictive biomarkers in transarterial chemoembolization?treated hepatocellular carcinoma patients"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-01"},"publish_date":"2019-04-01","publish_status":"0","recid":"1273","relation_version_is_last":true,"title":["Serum exosomal microRNA?122 and microRNA?21 as predictive biomarkers in transarterial chemoembolization?treated hepatocellular carcinoma patients"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:04:27.727691+00:00"}