{"created":"2023-05-15T16:38:58.070472+00:00","id":12755,"links":{},"metadata":{"_buckets":{"deposit":"9cc7dd3e-b77e-408c-aaa8-2e092d81433e"},"_deposit":{"created_by":2,"id":"12755","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"12755"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00012755","sets":["29:30"]},"author_link":["46973","46971","46972"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"748","bibliographicPageStart":"744","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"Archives of Gerontology and Geriatrics"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The phosphotyrosine signaling followed by various receptor activations conforms a unique signaling platform during metazoan evolution, and is crucial for animal development, maturation, and aging. Shc is the most versatile bipartite phosphotyrosine signal adaptor harboring phosphotrosine-biding (PTB) and Src-homology2 (SH2) domains. Among the Shc adaptor family members, p66-Shc is of potential interest in aging studies, since its deletion in mice resulted in a longer lifespan and/or higher quality of life in later stages of life. However, a few studies have examined the gene expression profiles of p66-Shc in aging tissues. Here, we quantified the expression levels of transcripts of Shc-related isoforms in the liver and brain of young adult, middle-aged, and aged rats, and found that p66-Shc gene expression is specifically up-regulated in the aged liver and brain. In the aged liver tissue, p66-Shc expression was also evident at the protein level, and accumulated in the soluble fraction of the aged tissue. These results indicate that p66-Shc is not only related to animal longevity but also affected during aging, and thus the repression of p66-Shc could become a potential target for an anti-aging strategy.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Archives of Gerontology and Geriatrics, 55(3), pp. 744-748; 2012","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Science Ireland"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"22130185","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.archger.2011.11.001","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2011 Elsevier Ireland Ltd. All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10637214","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01674943","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"18726976","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sone, Kiyoaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Mari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Nozomu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"AGG55_744.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AGG55_744.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/12755/files/AGG55_744.pdf"},"version_id":"e12aac51-be68-4d4b-be03-924087631635"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adapter","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-aging","subitem_subject_scheme":"Other"},{"subitem_subject":"Longevity","subitem_subject_scheme":"Other"},{"subitem_subject":"Phosphotyrosine","subitem_subject_scheme":"Other"},{"subitem_subject":"Signal transduction","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Selective upregulation of p66-Shc gene expression in the liver and brain of aged rats.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Selective upregulation of p66-Shc gene expression in the liver and brain of aged rats."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-12-26"},"publish_date":"2011-12-26","publish_status":"0","recid":"12755","relation_version_is_last":true,"title":["Selective upregulation of p66-Shc gene expression in the liver and brain of aged rats."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:56:44.145575+00:00"}