@article{oai:nagasaki-u.repo.nii.ac.jp:00001277,
 author = {Endo, Yushiro and Koga, Tomohiro and Ishida, Midori and Fujita, Yuya and Tsuji, Sosuke and Takatani, Ayuko and Shimizu, Toshimasa and Sumiyoshi, Remi and Igawa, Takashi and Umeda, Masataka and Fukui, Shoichi and Nishino, Ayako and Kawashiri, Shin-ya and Iwamoto, Naoki and Ichinose, Kunihiro and Tamai, Mami and Nakamura, Hideki and Origuchi, Tomoki and Kuwana, Masataka and Hosono, Yuji and Mimori, Tsuneyo and Kawakami, Atsushi},
 issue = {26},
 journal = {Medicine},
 month = {Jun},
 note = {Rationale: Among all dermatomyositis (DM) patients, antimelanoma differentiation-Associated gene 5 antibody (anti-MDA5 Ab) positive patients have significantly poor short-Term mortality, whereas they experience less relapses over the long term after the remission. We report the case of a patient with anti-MDA5 Ab-positive clinically amyopathic dermatomyositis (CADM) with the recurrence of interstitial lung disease (ILD) after 7 years of remission. There has been no case report of an anti-MDA5 Ab-positive DM patient with the recurrence of ILD after 7 years of long-Term remission. Patient concerns: A 70-year-old Japanese woman was diagnosed with anti-MDA5 Ab-positive CADM and ILD. After achieving 7 years long-Term remission, she was admitted to our department with erythema on the fingers and interstitial pneumonia. Her anti-MDA5 Ab titer was elevated. Diagnoses: We diagnosed recurrent CADM complicated with ILD. Interventions: We successfully treated her with 1,000 mg of methyl-prednisolone pulse and intravenous cyclophosphamide therapy followed by prednisolone 50 mg/day and an increase of cyclosporine. Outcomes: After that treatment, the patient's skin symptoms and interstitial pneumonia were relieved. All laboratory investigations such as ferritin, the serum markers of interstitial pneumonia (i.e., SP-A, SP-D), and the titer of anti-MDA5 Ab showed signs of improvement. Lessons: Her case suggests that careful physical examinations and monitoring the serum markers are important even after long-Term remission is achieved., Medicine, 97(26), art. no. e11024; 2018},
 title = {Recurrence of anti-MDA5 antibody-positive clinically amyopathic dermatomyositis after long-term remission},
 volume = {97},
 year = {2018}
}