{"created":"2023-05-15T16:39:00.505591+00:00","id":12813,"links":{},"metadata":{"_buckets":{"deposit":"4c1ff0bb-7e3c-45b7-bb56-6b30635a4be1"},"_deposit":{"created_by":2,"id":"12813","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"12813"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00012813","sets":["29:30"]},"author_link":["47076","47089","47087","47082","47074","47086","47075","47073","47088","47083","47078","47077","47084","47085","47079","47081","47080"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"46","bibliographicPageEnd":"18771","bibliographicPageStart":"18766","bibliographicVolumeNumber":"108","bibliographic_titles":[{"bibliographic_title":"Proceedings of the National Academy of Sciences of the United States of America"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mice deficient for interferon regulatory factor (Irf)2 (Irf2(-/-) mice) exhibit immunological abnormalities and cannot survive lymphocytic choriomeningitis virus infection. The pancreas of these animals is highly inflamed, a phenotype replicated by treatment with poly(I:C), a synthetic double-stranded RNA. Trypsinogen5 mRNA was constitutively up-regulated about 1,000-fold in Irf2(-/-) mice compared with controls as assessed by quantitative RT-PCR. Further knockout of IFNα/β receptor 1(Ifnar1) abolished poly(I:C)-induced pancreatitis but had no effect on the constitutive up-regulation of trypsinogen5 gene, indicating crucial type I IFN signaling to elicit the inflammation. Analysis of Ifnar1(-/-) mice confirmed type I IFN-dependent transcriptional activation of dsRNA-sensing pattern recognition receptor genes MDA5, RIG-I, and TLR3, which induced poly(I:C)-dependent cell death in acinar cells in the absence of IRF2. We speculate that Trypsin5, the trypsinogen5 gene product, leaking from dead acinar cells triggers a chain reaction leading to lethal pancreatitis in Irf2(-/-) mice because it is resistant to a major endogenous trypsin inhibitor, Spink3.","subitem_description_type":"Abstract"}]},"item_2_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1116273108/-/DCSupplemental.","subitem_description_type":"Other"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Proceedings of the National Academy of Sciences of the United States of America, 108(46), pp.18766-18771; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"National Academy of Sciences"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"22042864","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1073/pnas.1116273108","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10808769","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00278424","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"10916490","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hayashi, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasui, Kiyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murota, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Tohru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Duncan, Gordon S"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Tomoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Kazuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katayama, Ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ma, Yuhua"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chua, Koon Jiew"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suematsu, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimokawa, Isao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akira, Shizuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Yoshinao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mak, Tak Wah"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuyama, Toshifumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"PNAS108_18766.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PNAS108_18766.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/12813/files/PNAS108_18766.pdf"},"version_id":"1d492747-0db4-4ce8-b239-0a86d7883bfc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ca2+-binding proteins","subitem_subject_scheme":"Other"},{"subitem_subject":"Cathepsin B","subitem_subject_scheme":"Other"},{"subitem_subject":"IPS-1","subitem_subject_scheme":"Other"},{"subitem_subject":"TRIF","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-01-04"},"publish_date":"2012-01-04","publish_status":"0","recid":"12813","relation_version_is_last":true,"title":["Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:54:29.086140+00:00"}