{"created":"2023-05-15T16:39:00.635474+00:00","id":12816,"links":{},"metadata":{"_buckets":{"deposit":"649e5710-5873-43b7-a0ed-c7b89c7f291c"},"_deposit":{"created_by":2,"id":"12816","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"12816"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00012816","sets":["29:30"]},"author_link":["47109","47104","47101","47108","47099","47102","47107","47110","47106","47111","47100","47098","47103","47105"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"572","bibliographicPageStart":"564","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"Cytokine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Interferon regulatory factor (IRF)-4 is a member of the IRF transcription factor family, whose expression is primarily restricted to lymphoid and myeloid cells. In T-cells, IRF-4 expression is induced by T-cell receptor (TCR) cross-linking or treatment with phorbol-12-myristate-13-acetate (PMA)/Ionomycin, and IRF-4 is thought to be a critical factor for various functions of T-cells. To elucidate the IRF-4 functions in human adult T-cell leukemia virus type 1 (HTLV-1)-infected T-cells, which constitutively express IRF-4, we isolated IRF-4-binding proteins from T-cells, using a tandem affinity purification (TAP)-mass spectrometry strategy. Fourteen proteins were identified in the IRF-4-binding complex, including endogenous IRF-4 and the nuclear factor-kappaB (NF-κB) family member, c-Rel. The specific association of IRF-4 with c-Rel was confirmed by immunoprecipitation experiments, and IRF-4 was shown to enhance the c-Rel-dependent binding and activation of the interleukin-4 (IL-4) promoter region. We also demonstrated that IL-2 production was also enhanced by exogenously-expressed IRF-4 and c-Rel in the presence of P/I, in T-cells, and that the optimal IL-2 and IL-4 productions in vivo was IRF-4-dependent using IRF-4-/- mice. These data provide molecular evidence to support the clinical observation that elevated expression of c-Rel and IRF-4 is associated with the prognosis in adult T-cell leukemia/lymphoma (ATLL) patients, and present possible targets for future gene therapy.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cytokine, 56(3), pp.564-572; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd."}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"21890374","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.cyto.2011.08.014","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2011 Elsevier Ltd. All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10794201","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10434666","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"10960023","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shindo, Hisakazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasui, Kiyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Kazuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honma, Kiri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yui, Katsuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ma, Yuhua"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chua, Koon Jiew"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Yoshinao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aihara, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagayasu, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuyama, Toshifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Hideki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"Cytokine56_564.pdf","filesize":[{"value":"819.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Cytokine56_564.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/12816/files/Cytokine56_564.pdf"},"version_id":"8f60fd9f-b72a-4618-9263-920fc84a36ed"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adult T-cell leukemia/lymphoma (ATLL)","subitem_subject_scheme":"Other"},{"subitem_subject":"C-Rel","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-2","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-4","subitem_subject_scheme":"Other"},{"subitem_subject":"Interferon regulatory factor (IRF)-4","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-01-04"},"publish_date":"2012-01-04","publish_status":"0","recid":"12816","relation_version_is_last":true,"title":["Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:54:57.182330+00:00"}