{"created":"2023-05-15T16:30:14.911021+00:00","id":1308,"links":{},"metadata":{"_buckets":{"deposit":"afa45f07-b634-4b48-87cf-1403ff5ef35c"},"_deposit":{"created_by":2,"id":"1308","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1308"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001308","sets":["10:11"]},"author_link":["6143","6144","6138","6142","6139","6141","6140"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1328","bibliographicPageStart":"1319","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"European Journal of Immunology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Interferon regulatory factor 4 (IRF4) has critical roles in immune cell differentiation and function and is indispensable for clonal expansion and effector function in T cells. Here, we demonstrate that the AKT pathway is impaired in murine CD8+ T cells lacking IRF4. The expression of phosphatase and tensin homolog (PTEN), a negative regulator of the AKT pathway, was elevated in Irf4?/? CD8+ T cells. Inhibition of PTEN partially rescued downstream events, suggesting that PTEN constitutes a checkpoint in the IRF4-mediated regulation of cell signaling. Despite the clonal expansion defect, in the \nabsence of IRF4, memory-like CD8+ T cells could be generated and maintained, although unable to expand in recall responses. The homeostatic proliferation of naive Irf4?/? CD8+ T cells was impaired, whereas their number eventually reached a level similar to that of wild-type CD8+ T cells. Conversely, memory-like Irf4?/? CD8+ T cells underwent homeostatic proliferation in a manner similar to that of wild-type memory CD8+ T cells. These results suggest that IRF4 regulates the clonal expansion of CD8+ T cells at least in part via the AKT signaling pathway. Moreover, IRF4 regulates the homeostatic proliferation of naive CD8+ T cells, whereas the maintenance of memory CD8+ T cells is IRF4-independent.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"European Journal of Immunology, 48(8), pp.1319-1328; 2018","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/eji.201747120","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.  This is the peer reviewed version of the following article:European Journal of Immunology, 48(8), pp.1319-1328; 2018 , which has been published in final form at 10.1002/eji.201747120. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00142980","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyakoda, Mana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honma, Kiri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akbari, Masoud"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Kazumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuyama, Toshifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yui, Katsuyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"EJI48_1319.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"EJI48_1319.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1308/files/EJI48_1319.pdf"},"version_id":"f36bbb72-daa2-4ab9-8215-5e3ccf3b0beb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD8+Tcells","subitem_subject_scheme":"Other"},{"subitem_subject":"Homeostasis","subitem_subject_scheme":"Other"},{"subitem_subject":"Memory cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Signal transduction","subitem_subject_scheme":"Other"},{"subitem_subject":"Transcription factors","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Differential requirements for IRF4 in the clonal expansion and homeostatic proliferation of naive and memory murine CD8+ T?cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Differential requirements for IRF4 in the clonal expansion and homeostatic proliferation of naive and memory murine CD8+ T?cells"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-01"},"publish_date":"2019-09-01","publish_status":"0","recid":"1308","relation_version_is_last":true,"title":["Differential requirements for IRF4 in the clonal expansion and homeostatic proliferation of naive and memory murine CD8+ T?cells"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:03:45.979872+00:00"}