{"created":"2023-05-15T16:39:14.897815+00:00","id":13129,"links":{},"metadata":{"_buckets":{"deposit":"0c9f2d0a-e6e7-4332-bb75-8ba2cd9facc2"},"_deposit":{"created_by":2,"id":"13129","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"13129"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00013129","sets":["29:30"]},"author_link":["47724","47718","47721","47723","47720","47722","47719"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"44","bibliographicPageStart":"37","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Biomedical Research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The TNF-family molecule, Receptor Activator of Nuclear factor κ B Ligand (RANKL) is known as a key regulator for bone remodeling, and is essential for the development and activation of osteoclasts. In this study, we examined the regulation of RANKL in primary human bone marrow adipocytes and the relationship between bone marrow adipocytes and bone metabolism. RANKL expression and the RANKL/osteoprotegerin (OPG) mRNA ratio in marrow adipocytes increased following dexamethasone treatment. In co-cultures of human osteoclast precursors and bone marrow adipocytes with dexamethasone, osteoclast precursors differentiated to TRAP-positive multi-nuclear cells. Moreover, the ability of bone resorption was confirmed in co-culture in flasks coated with calcium phosphate film. Osteoclast precursor differentiation and bone resorption were blocked by RANKL antibody pretreatment. TRAP-positive multinuclear cells did not form in co-culture without cell-to-cell contact conditions. We conclude that primary human bone marrow adi-pocytes have the ability to promote osteoclast differentiation and activities, similar to osteoblasts and other RANKL-expressing cells.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biomedical Research, 32(1), pp.37-44; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Biomedical Research Foundation"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2220/biomedres.32.37","subitem_relation_type_select":"DOI"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10069/26698"}]}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2011 Biomedical Research Press"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11126935","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03886107","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"バイオメディカルリサーチプレス"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Goto, Hisataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osaki, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukushima, Tatsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Kazutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hozumi, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Baba, Hideo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shindo, Hiroyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"BioRes32_37.pdf","filesize":[{"value":"8.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BioRes32_37.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/13129/files/BioRes32_37.pdf"},"version_id":"2451151b-3616-49dd-8811-fa043c6eeb43"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Human bone marrow adipocytes support dexamethasone-induced osteoclast differentiation and function through RANKL expression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human bone marrow adipocytes support dexamethasone-induced osteoclast differentiation and function through RANKL expression"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-05-25"},"publish_date":"2011-05-25","publish_status":"0","recid":"13129","relation_version_is_last":true,"title":["Human bone marrow adipocytes support dexamethasone-induced osteoclast differentiation and function through RANKL expression"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:50:53.536056+00:00"}