{"created":"2023-05-15T16:39:27.089941+00:00","id":13357,"links":{},"metadata":{"_buckets":{"deposit":"9bc56646-efc0-41cc-918d-6844515b35c6"},"_deposit":{"created_by":2,"id":"13357","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"13357"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00013357","sets":["73:74"]},"author_link":["48193","48195","48190","48188","48191","48194","48192","48196","48189"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1369","bibliographicPageStart":"1359","bibliographicVolumeNumber":"156","bibliographic_titles":[{"bibliographic_title":"Archives of virology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Influenza A virus (IAV) infection is a major public health threat leading to significant morbidity and mortality. The emergence of drug-resistant virus strains highlights the urgent need to develop novel antiviral drugs with alternative modes of action. Pentagalloylglucose (PGG), a naturally occurring polyphenolic compound, possesses a broad spectrum of biological activities. In this study, we found that PGG has anti-influenza-virus activity, and investigated its possible mechanism(s) of action in vitro. Both pre-incubation of virus prior to infection and post-exposure of infected cells with PGG significantly inhibited virus yields. Influenza-virus-induced hemagglutination of chicken red blood cells was inhibited by PGG treatment, suggesting that PGG can inhibit IAV infection by interacting with the viral hemagglutinin. PGG did not affect viral protein synthesis or nuclear transport of viral nucleoprotein (NP) but greatly reduced plasma membrane accumulation of NP protein at the late stage of the replication cycle. Furthermore, PGG significantly reduced virus budding and progeny virus release from infected cells. This study revealed for the first time that PGG can inhibit IAV replication with a dual mode of action and offers new insights into its underlying mechanisms of antiviral action.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Archives of virology, 156(8), pp.1359-1369; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"21479599","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00705-011-0989-9","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Springer-Verlag 2011"},{"subitem_rights":"The original publication is available at www.springerlink.com"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00548901","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03048608","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14328798","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Liu, Ge"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Xiong, Sheng"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Xiang, Yang-Fei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Guo, Chao-Wan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ge, Feng"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yang, Chong-Ren"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhang, Ying-Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Yi-Fei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitazato, Kaio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"ArcVio156_1359.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ArcVio156_1359.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/13357/files/ArcVio156_1359.pdf"},"version_id":"24900512-a9c3-47a1-be29-b95c6215da91"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Influenza A virus","subitem_subject_scheme":"Other"},{"subitem_subject":"PGG","subitem_subject_scheme":"Other"},{"subitem_subject":"antiviral activity","subitem_subject_scheme":"Other"},{"subitem_subject":"mechanisms of action","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus."}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-09-01"},"publish_date":"2012-09-01","publish_status":"0","recid":"13357","relation_version_is_last":true,"title":["Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:06:50.710870+00:00"}