{"created":"2023-05-15T16:39:27.563799+00:00","id":13368,"links":{},"metadata":{"_buckets":{"deposit":"e5d7e927-2a41-4e94-8f2b-e48637e240a5"},"_deposit":{"created_by":2,"id":"13368","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"13368"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00013368","sets":["29:30"]},"author_link":["48283","48280","48281","48275","48278","48282","48277","48276","48279","48274"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"712","bibliographicPageStart":"707","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"Internal Medicine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background Tobacco smoking is a major risk factor for atherosclerotic and cardiovascular disease. Studies have found evidence that smoking cessation is associated with weight gain, which is itself a leading cause of cardiovascular disease. Aim The present study sought to determine how smoking cessation and associated weight gain affect adiponectin levels and insulin resistance. Methods Fifty-two male habitual smokers were treated for 2 months with transdermal nicotine patches, and the 28 subjects who successfully quit smoking were analyzed. Subjects were divided into two sub-groups according to their weight change: weight maintainers and weight gainers. Serum adiponectin levels and the homeostasis model assessment ratio (HOMA-R) were evaluated at the beginning of the study, and at 1 week and 9 weeks after cessation of patch use. Results In weight gainers (n=18), serum adiponection levels tended to increase at 1 week after the end of treatment (mean difference 0.4±1.0 μg/mL, p=0.08). Moreover, after 9 weeks, adiponectin levels were significantly decreased in weight gainers (mean difference between 1 week and 9 weeks 0.8±0.9 μg/mL, p=0.002). In weight maintainers, adiponectin levels increased slightly after smoking cessation, but changes were not significant. In weight gainers, HOMA-R index was significantly increased (mean difference between baseline and 9 weeks 0.4±0.7, p=0.01), while in weight maintainers, HOMA-R index showed no differences throughout the study. Conclusion Our findings suggest that the adverse effects of weight gain attenuate some of the beneficial effects of smoking cessation.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Internal Medicine, 50(7), pp.707-712; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本内科学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2169/internalmedicine.50.4600","subitem_relation_type_select":"DOI"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10069/26687"}]}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2011 by The Japanese Society of Internal Medicine"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10827774","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09182918","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"The Japanese Society of Internal Medicine"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inoue, Keita"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeshima, Fuminao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadota, Koichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoda, Aya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tatsuta, Yoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagaura, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshioka, Sumako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamichi, Seiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Kazuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ozono, Yoshiyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"IntMed50_707.pdf","filesize":[{"value":"140.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"IntMed50_707.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/13368/files/IntMed50_707.pdf"},"version_id":"2eeecf64-5cfa-4a53-9974-7ed8f6e61e26"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adiponectin","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulin resistance","subitem_subject_scheme":"Other"},{"subitem_subject":"Smoking cessation","subitem_subject_scheme":"Other"},{"subitem_subject":"Weight gain","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Early Effects of Smoking Cessation and Weight Gain on Plasma Adiponectin Levels and Insulin Resistance","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Early Effects of Smoking Cessation and Weight Gain on Plasma Adiponectin Levels and Insulin Resistance"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-28"},"publish_date":"2011-07-28","publish_status":"0","recid":"13368","relation_version_is_last":true,"title":["Early Effects of Smoking Cessation and Weight Gain on Plasma Adiponectin Levels and Insulin Resistance"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:53:04.353136+00:00"}