{"created":"2023-05-15T16:39:30.125609+00:00","id":13418,"links":{},"metadata":{"_buckets":{"deposit":"921310c2-6016-4c6d-b043-41b575aa17cf"},"_deposit":{"created_by":2,"id":"13418","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"13418"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00013418","sets":["10:11"]},"author_link":["48549","48547","48546","48542","48548","48550","48541","48545","48544","48543"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"110","bibliographicPageStart":"105","bibliographicVolumeNumber":"224","bibliographic_titles":[{"bibliographic_title":"The Tohoku Journal of Experimental Medicine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Osteoporosis is a common disorder in aging populations that imposes considerable health problems. Tartrate-resistant acid phosphatase type 5b (TRAP-5b) is derived from osteoclasts, and is involved in normal bone homeostasis. Recently, a novel assay system for TRAP-5b, the fragments absorbed immunocapture enzymatic assay method, has been developed. To evaluate the suitability of TRAP-5b as a screening marker for bone mineral density (BMD), we explored the correlations between serum TRAP-5b concentrations and laboratory findings, body mass index, or BMD in 462 community-dwelling elderly individuals (249 men and 213 women, age 73.4 ± 6.5 years) who participated in a regular medical screening program. By multivariate linear regression analysis adjusted for confounding factors, TRAP-5b was significantly correlated with body mass index (β = -0.005, p = 0.043), alkaline phosphatase, a marker for osteoid formation and calcification (β = 0.001, p < 0.001), and triglyceride (β = -0.097, p = 0.016) in men, and with body mass index (β = -0.009, p = 0.025), alkaline phosphatase (β = 0.001, p < 0.001), calcium (β = -0.059, p = 0.039), and bone trabecular area ratio (β = -0.47, p = 0.025) in women. In conclusion, the elevated serum level of TRAP-5b is independently correlated with the decreased BMD in women, but not in men. Because measurement of TRAP-5b is not affected by food intake, and blood samples can be collected at any time of the day, we suggest the suitability of serum TRAP-5b as a simple marker for the evaluation of BMD in women.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"The Tohoku Journal of Experimental Medicine, 224(2), pp.105-110; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tohoku University Medical Press"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1620/tjem.224.105","subitem_relation_type_select":"DOI"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10069/32740"}]}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2011 Tohoku University Medical Press."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00863920","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00408727","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13493329","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"東北ジャーナル刊行会"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Irie, Sumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashida, Naomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shinkawa, Tetsuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taira, Yasuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekitani, Yui"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Teraoka, Seitaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashiguchi, Kanami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morishita, Michiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takamura, Noboru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"TJEM224_105.pdf","filesize":[{"value":"352.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"TJEM224_105.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/13418/files/TJEM224_105.pdf"},"version_id":"5dabde4f-65f3-4355-9043-d8a29910f240"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bone mineral density","subitem_subject_scheme":"Other"},{"subitem_subject":"Elderly","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoporosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Screening","subitem_subject_scheme":"Other"},{"subitem_subject":"Tartrate-resistant acid phosphatase type 5b","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-08-08"},"publish_date":"2011-08-08","publish_status":"0","recid":"13418","relation_version_is_last":true,"title":["Suitability of Tartrate-Resistant Acid Phosphatase Type 5b as a Screening Marker for Bone Mineral Density in Community-Dwelling Elderly Individuals"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:59:14.293708+00:00"}