@article{oai:nagasaki-u.repo.nii.ac.jp:00013465,
 author = {Saito, Takashi and Suemoto, Takahiro and Brouwers, Nathalie and Sleegers, Kristel and Funamoto, Satoru and Mihira, Naomi and Matsuba, Yukio and Yamada, Kazuyuki and Nilsson, Per and Takano, Jiro and Nishimura, Masaki and Iwata, Nobuhisa and Van, Broeckhoven  Christine and Ihara, Yasuo and Saido, Takaomi C},
 issue = {8},
 journal = {Nature Neuroscience},
 month = {Aug},
 note = {The amyloid-β peptide Aβ42 is known to be a primary amyloidogenic and pathogenic agent in Alzheimer's disease. However, the role of Aβ43, which is found just as frequently in the brains of affected individuals, remains unresolved. We generated knock-in mice containing a pathogenic presenilin-1 R278I mutation that causes overproduction of Aβ43. Homozygosity was embryonic lethal, indicating that the mutation involves a loss of function. Crossing amyloid precursor protein transgenic mice with heterozygous mutant mice resulted in elevated Aβ43, impairment of short-term memory and acceleration of amyloid-β pathology, which accompanied pronounced accumulation of Aβ43 in plaque cores similar in biochemical composition to those observed in the brains of affected individuals. Consistently, Aβ43 showed a higher propensity to aggregate and was more neurotoxic than Aβ42. Other pathogenic presenilin mutations also caused overproduction of Aβ43 in a manner correlating with Aβ42 and with the age of disease onset. These findings indicate that Aβ43, an overlooked species, is potently amyloidogenic, neurotoxic and abundant in vivo., Nature Neuroscience, 14(8), pp.1023-1032; 2011},
 pages = {1023--1032},
 title = {Potent amyloidogenicity and pathogenicity of Aβ43.},
 volume = {14},
 year = {2011}
}