{"created":"2023-05-15T16:39:35.885555+00:00","id":13550,"links":{},"metadata":{"_buckets":{"deposit":"5b5f3f0d-95f9-485d-9a63-2871ee04ead5"},"_deposit":{"created_by":2,"id":"13550","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"13550"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00013550","sets":["29:30"]},"author_link":["48845","48842","48851","48844","48846","48850","48843","48847","48849","48848"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"60","bibliographicPageStart":"51","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Acta Histochemica et Cytochemica"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Thalidomide is clinically recognized as a therapeutic agent for multiple myeloma and has been known to exert anti-angiogenic actions. Recent studies have suggested the involvement of angiogenesis in the progression of peritoneal fibrosis. The present study investigated the effects of thalidomide on the development of peritoneal fibrosis induced by injection of chlorhexidine gluconate (CG) into the mouse peritoneal cavity every other day for 3 weeks. Thalidomide was given orally every day. Peritoneal tissues were dissected out 21 days after CG injection. Expression of CD31 (as a marker of endothelial cells), proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), α-smooth muscle actin (as a marker of myofibroblasts), type III collagen and transforming growth factor (TGF)-β was examined using immunohistochemistry. CG group showed thickening of the submesothelial zone and increased numbers of vessels and myofibroblasts. Large numbers of VEGF-, PCNA-, and TGF-β-positive cells were observed in the submesothelial area. Thalidomide treatment significantly ameliorated submesothelial thickening and angiogenesis, and decreased numbers of PCNA- and VEGF-expressing cells, myofibroblasts, and TGF-β-positive cells. Moreover, thalidomide attenuated peritoneal permeability for creatinine, compared to the CG group. Our results indicate the potential utility of thalidomide for preventing peritoneal fibrosis.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta Histochemica et Cytochemica, 44(2), pp.51-60; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Society of Histochemistry and Cytochemistry"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"21614166","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1267/ahc.10030","subitem_relation_type_select":"DOI"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10069/26735"}]}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2011 By the Japan Society of Histochemistry and Cytochemistry"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508022","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00445991","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13475800","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"日本組織細胞化学会"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Arai, Hideyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furusu, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishino, Tomoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Obata, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakazawa, Yuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakazawa, Masayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirose, Misaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abe, Katsushige"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koji, Takehiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Shigeru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"AHC44_51.pdf","filesize":[{"value":"796.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AHC44_51.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/13550/files/AHC44_51.pdf"},"version_id":"1a2857c1-4d7e-487c-87a4-20c057bed2fb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PCNA","subitem_subject_scheme":"Other"},{"subitem_subject":"Peritoneal fibrosis","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β","subitem_subject_scheme":"Other"},{"subitem_subject":"Thalidomide","subitem_subject_scheme":"Other"},{"subitem_subject":"VEGF","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Thalidomide prevents the progression of peritoneal fibrosis in mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Thalidomide prevents the progression of peritoneal fibrosis in mice."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-08-31"},"publish_date":"2011-08-31","publish_status":"0","recid":"13550","relation_version_is_last":true,"title":["Thalidomide prevents the progression of peritoneal fibrosis in mice."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:12:08.733144+00:00"}