@article{oai:nagasaki-u.repo.nii.ac.jp:00013566,
 author = {Furugen, Reiko and Hayashida, Hideaki and Yoshii, Yumiko and Saito, Toshiyuki},
 issue = {2},
 journal = {FEMS Microbiology Letters},
 month = {Aug},
 note = {Resistin is an adipokine that induces insulin resistance in mice. In humans, resistin is not produced in adipocytes, but in various leukocytes instead, and it acts as a proinflammatory molecule. The present investigation demonstrated high levels of resistin in culture supernatants of neutrophils that are stimulated by a highly leukotoxic strain of Aggregatibacter actinomycetemcomitans. In contrast, the level of resistin was remarkably low when neutrophils were exposed to two other strains that produce minimal levels of leukotoxin and a further isogenic mutant strain incapable of producing leukotoxin. Pretreatment of neutrophils with a monoclonal antibody to CD18, β chain of lymphocyte function-associated molecule 1 (LFA-1), or an Src family tyrosine kinase inhibitor before incubation with the highly leukotoxic strain inhibited the release of resistin. These results show that A. actinomycetemcomitans-expressed leukotoxin induces extracellular release of human neutrophil-derived resistin by interacting with LFA-1 on the surface of neutrophils and, consequently, activating Src family tyrosine kinases., FEMS Microbiology Letters, 321(2), pp.175-182; 2011},
 pages = {175--182},
 title = {Neutrophil-derived resistin release induced by Aggregatibacter actinomycetemcomitans.},
 volume = {321},
 year = {2011}
}