{"created":"2023-05-15T16:39:36.589922+00:00","id":13566,"links":{},"metadata":{"_buckets":{"deposit":"85cac86f-adca-48be-b5d1-58f947c97329"},"_deposit":{"created_by":2,"id":"13566","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"13566"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00013566","sets":["27:28"]},"author_link":["48987","48988","48986","48989"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"182","bibliographicPageStart":"175","bibliographicVolumeNumber":"321","bibliographic_titles":[{"bibliographic_title":"FEMS Microbiology Letters"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Resistin is an adipokine that induces insulin resistance in mice. In humans, resistin is not produced in adipocytes, but in various leukocytes instead, and it acts as a proinflammatory molecule. The present investigation demonstrated high levels of resistin in culture supernatants of neutrophils that are stimulated by a highly leukotoxic strain of Aggregatibacter actinomycetemcomitans. In contrast, the level of resistin was remarkably low when neutrophils were exposed to two other strains that produce minimal levels of leukotoxin and a further isogenic mutant strain incapable of producing leukotoxin. Pretreatment of neutrophils with a monoclonal antibody to CD18, β chain of lymphocyte function-associated molecule 1 (LFA-1), or an Src family tyrosine kinase inhibitor before incubation with the highly leukotoxic strain inhibited the release of resistin. These results show that A. actinomycetemcomitans-expressed leukotoxin induces extracellular release of human neutrophil-derived resistin by interacting with LFA-1 on the surface of neutrophils and, consequently, activating Src family tyrosine kinases.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"FEMS Microbiology Letters, 321(2), pp.175-182; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell Publishing Inc."}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"21658109","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1574-6968.2011.02334.x","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved"},{"subitem_rights":"The definitive version is available at www.blackwell-synergy.com"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00193861","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03781097","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"15746968","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Furugen, Reiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashida, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshii, Yumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Toshiyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"FEMS321_175.pdf","filesize":[{"value":"313.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FEMS321_175.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/13566/files/FEMS321_175.pdf"},"version_id":"baafb7b1-0101-4654-b69c-8bd8905681d5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aggregatibacter actinomycetemcomitans","subitem_subject_scheme":"Other"},{"subitem_subject":"LFA-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Neutrophil","subitem_subject_scheme":"Other"},{"subitem_subject":"Resistin","subitem_subject_scheme":"Other"},{"subitem_subject":"Src family tyrosine kinase","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neutrophil-derived resistin release induced by Aggregatibacter actinomycetemcomitans.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neutrophil-derived resistin release induced by Aggregatibacter actinomycetemcomitans."}]},"item_type_id":"2","owner":"2","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-09-01"},"publish_date":"2012-09-01","publish_status":"0","recid":"13566","relation_version_is_last":true,"title":["Neutrophil-derived resistin release induced by Aggregatibacter actinomycetemcomitans."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:09:53.115939+00:00"}