{"created":"2023-05-15T16:29:24.274060+00:00","id":136,"links":{},"metadata":{"_buckets":{"deposit":"4fcfe31b-e52a-4765-8dd8-d4813c117c44"},"_deposit":{"created_by":2,"id":"136","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"136"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000136","sets":["35:36"]},"author_link":["604","599","598","590","607","595","601","602","610","589","596","592","591","603","594","597","593","608","605","611","600","613","609","612","606"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"art.no.1980","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Frontiers in Immunology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The protective or pathogenic role of T lymphocytes during the acute phase of dengue virus (DENV) infection has not been fully understood despite its importance in immunity and vaccine development\n. Objectives: This study aimed to clarify the kinetics of T lymphocyte subsets during the clinical course of acute dengue patients. Study design: In this hospital-based cohort study, 59 eligible Vietnamese \ndengue patients were recruited and admitted. They were investigated and monitored for T cell subsets and a panel of clinical and laboratory parameters every day until discharged and at post-discharge from \nthe hospital. Results: We described for the first time the kinetics of T cell response during the clinical course of DENV infection. Severe cases showed significantly lower levels of effector CD8+ T \ncells compared to mild cases at day ?1 (p = 0.017) and day 0 (p = 0.033) of defervescence. After defervescence, these cell counts in severe cases increased rapidly to equalize with the levels \nof mild cases. Our results also showed a decline in total CD4+ T, Th1, Th1/17 cells during febrile phase of dengue patients compared to normal controls or convalescent phase. On the other hand, Th2 cells increased during DENV infection until convalescent phase. Cytokines such as interferon-γ, IL-12p70, IL-5, IL-23, IL-17A showed tendency to decrease on day 0 and 1 compared with convalescence and only IL-5 showed significance indicating the production during acute phase was not systemic.Conclusion: With a rigorous study design, we uncovered the kinetics of T cells in natural DENV infection. Decreased number of effector CD8+ T cells in the early phase of infection and subsequent increment after defervescence day probably associated with the T cell migration in DENV infection.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Frontiers in Immunology, 11, art.no.1980; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media S.A."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3389/fimmu.2020.01980","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2020 Manh, Weiss, Thuong, Mizukami, Dumre, Luong, Thanh, Thang,Huu, Phuc, Nhung, Mai, Truong, Ngu, Quoc, Ha, Ton, An, Halhouli, Quynh,Kamel, Karbwang, Huong, Huy and Hirayama. This is an open-access article distributedunder the terms of the Creative Commons Attribution License(CC BY). The use, distribution or reproduction in other forums is permitted, provided the originalauthor(s) and the copyright owner(s) are credited and that the original publicationin this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"16643224","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Manh, Dao Huy"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Weiss, Lan Nguyen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Thuong, Nguyen Van"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizukami, Shusaku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dumre, Shyam Prakash"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Luong, Quang Chan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Thanh, Le Chi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Thang, Cao Minh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huu, Pham Thanh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Phuc, Le Hong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nhung, Cao Thi Hong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mai, Nguyen Thi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Truong, Nguyen Quang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ngu, Vu Thien Thu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Quoc, Do Kien"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ha, Tran Thi Ngoc"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ton, Tran"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"An, Tran Van"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Halhouli, Oday"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Quynh, Le Nhat"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamel, Mohamed Gomaa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Karbwang, Juntra"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huong, Vu Thi Que"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huy, Nguyen Tien"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirayama, Kenji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-16"}],"displaytype":"detail","filename":"Fnimmu11_1980.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Fnimmu11_1980.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/136/files/Fnimmu11_1980.pdf"},"version_id":"17453c62-eeb5-4262-99d8-e045ed6f7d81"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dengue","subitem_subject_scheme":"Other"},{"subitem_subject":"T helper cells (Th cells)","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"T cell subsets","subitem_subject_scheme":"Other"},{"subitem_subject":"cytoxic T cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Kinetics of CD4+ T Helper and CD8+ Effector T Cell Responses in Acute Dengue Patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Kinetics of CD4+ T Helper and CD8+ Effector T Cell Responses in Acute Dengue Patients"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-23"},"publish_date":"2020-10-23","publish_status":"0","recid":"136","relation_version_is_last":true,"title":["Kinetics of CD4+ T Helper and CD8+ Effector T Cell Responses in Acute Dengue Patients"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:21:25.720243+00:00"}