{"created":"2023-05-15T16:30:17.464015+00:00","id":1362,"links":{},"metadata":{"_buckets":{"deposit":"51b5f9fe-6215-430d-bbe0-9aa298e7c54d"},"_deposit":{"created_by":2,"id":"1362","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1362"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001362","sets":["8:9"]},"author_link":["6466","6457","6456","6465","6464","6458","6459","6461","6462","6455","6468","6467","6460","6463"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"170","bibliographicPageStart":"161","bibliographicVolumeNumber":"144","bibliographic_titles":[{"bibliographic_title":"Diabetes Research and Clinical Practice"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims: To evaluate the glycaemic control of combination therapy with basal insulin and liraglutide, and to explore the factors predictive of efficacy in patients with type 2 diabetes when switched from longstanding basal-bolus insulin therapy. Methods: We studied 41 patients who switched from basal-bolus insulin therapy of more than 3 years to basal insulin/liraglutide combination therapy. Glycaemic control was evaluated at 6 months after switching therapy and used to subdivide the patients into good-responders (HbA1c <7.0% or 1.0% decrease) and poor-responders (the rest of participants). To evaluate the glucose-dependent insulin/glucagon responses without/with liraglutide, a 75-g oral glucose tolerance test (OGTT) was performed twice, before (1st-OGTT) and 2-days after (2nd-OGTT) liraglutide administration. Results: Twenty-eight patients (68.3%) were identified as good-responders. No differences were found in baseline characteristics including insulin/glucagon responses during 1st-OGTT between the groups. 2nd-OGTT revealed that paradoxical hyperglucagonemia were significantly improved in both groups, but significant increases in insulin secretory response were observed only in good-responders. Logistic regression analyses revealed that the improvement of the insulin-response during 2nd-OGTT compared to that during 1st-OGTT is associated with the good-responder. Conclusions: Enhancement of glucose-dependent insulin-response under liraglutide administration is a potential predictor of long-term glycaemic control after switching the therapies.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Diabetes Research and Clinical Practice, 144, pp.161-170; 2018","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.diabres.2018.08.015","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2018 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01688227","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Horie, Ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Haraguchi, Ai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sako, Ayaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akeshima, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Niri, Tetsuro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shigeno, Riyoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Ayako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nozaki, Aya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Natsuda, Shoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akazawa, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Yoshitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ando, Takao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abiru, Norio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"DRCP144_161.pdf","filesize":[{"value":"493.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DRCP144_161.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1362/files/DRCP144_161.pdf"},"version_id":"256baff9-6c8e-4d0a-9744-84ac652c94f4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Basal","subitem_subject_scheme":"Other"},{"subitem_subject":"Bolus","subitem_subject_scheme":"Other"},{"subitem_subject":"GLP-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucagon","subitem_subject_scheme":"Other"},{"subitem_subject":"Liraglutide","subitem_subject_scheme":"Other"},{"subitem_subject":"Proinsulin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Predictive factors of efficacy of combination therapy with basal insulin and liraglutide in type 2 diabetes when switched from longstanding basal-bolus insulin: Association between the responses of β- and α-cells to GLP-1 stimulation and the glycaemic control at 6?months after switching therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Predictive factors of efficacy of combination therapy with basal insulin and liraglutide in type 2 diabetes when switched from longstanding basal-bolus insulin: Association between the responses of β- and α-cells to GLP-1 stimulation and the glycaemic control at 6?months after switching therapy"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-01"},"publish_date":"2019-11-01","publish_status":"0","recid":"1362","relation_version_is_last":true,"title":["Predictive factors of efficacy of combination therapy with basal insulin and liraglutide in type 2 diabetes when switched from longstanding basal-bolus insulin: Association between the responses of β- and α-cells to GLP-1 stimulation and the glycaemic control at 6?months after switching therapy"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:03:13.199843+00:00"}