{"created":"2023-05-15T16:39:54.536428+00:00","id":13958,"links":{},"metadata":{"_buckets":{"deposit":"0f53e07c-3f86-46e3-b5bb-12b726ff4303"},"_deposit":{"created_by":2,"id":"13958","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"13958"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00013958","sets":["8:9"]},"author_link":["50078","50079","50067","50069","50077","50066","50075","50072","50068","50065","50071","50073","50076","50070","50074"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1117","bibliographicPageStart":"1108","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Leukemia & Lymphoma"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aberrant overexpression of membrane-associated mucin (MUC1) is implicated in the pathogenesis of cancer, particularly of adenocarcinomas. Adult T-cell leukemia/lymphoma (ATL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), exhibits invasive tropism into various organs, resulting in disease progression and resistance to treatment. In the present study, we showed that MUC1 is overexpressed exclusively in cells of ATL among hematological malignancies. Furthermore, increased expression of MUC1 correlated with a poor prognosis, suggesting MUC1 to be a prognostic marker in ATL. Various functional analyses with knockdown experiments using a specific siRNA for MUC1 revealed that MUC1 is involved in cell growth, cell aggregation, and resistance to apoptosis. Although it has been shown that the anti-adhesive properties of MUC1 facilitate migration and metastasis of tumor cells, our findings indicated that MUC1 contributes to cell-cell adhesion. Mucins thus seem to play a role in the pathogenesis and/or progression of ATL.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Leukemia & Lymphoma, 52(6), pp.1108-1117; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Informa UK"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"21599593","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3109/10428194.2011.559671","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2011 Informa UK, Ltd."},{"subitem_rights":"This is an electronic version of an article published in Leukemia & Lymphoma, 52(6), pp.1108-1117; 2011. Leukemia & Lymphoma is available online at: http://dx.doi.org/10.3109/10428194.2011.559671"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1077558X","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10428194","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"10292403","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasegawa, Hiroo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komoda, Minori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Yasuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yonezawa, Suguru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsutsumida, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagai, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Atogami, Sunao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuruda, Kazuto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osaka, Akemi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagihara, Katsunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imaizumi, Yoshitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsukasaki, Kunihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamihira, Shimeru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"LeuLym52_1108.pdf","filesize":[{"value":"904.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"LeuLym52_1108.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/13958/files/LeuLym52_1108.pdf"},"version_id":"5cb92b6b-2cf1-4463-9075-241f601bcb46"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adhesion molecules","subitem_subject_scheme":"Other"},{"subitem_subject":"adult T-cell leukemia/lymphoma","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"MUC1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells."}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-07-01"},"publish_date":"2012-07-01","publish_status":"0","recid":"13958","relation_version_is_last":true,"title":["Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T00:28:06.738525+00:00"}