{"created":"2023-05-15T16:39:57.633155+00:00","id":14031,"links":{},"metadata":{"_buckets":{"deposit":"d3090197-1ab7-45da-a1fe-e925430b3bfe"},"_deposit":{"created_by":2,"id":"14031","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"14031"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00014031","sets":["10:11"]},"author_link":["50272","50266","50271","50274","50273","50265","50270","50267","50268","50269"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"573","bibliographicPageStart":"565","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"International Immunology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In neuromyelitis optica (NMO), B-cell autoimmunity to aquaporin-4 (AQP4) has been shown to be essential. However, the role of T cells remains ambiguous. Here, we first showed an increase in CD69+ activated T cells in PBMCs during NMO relapses. Next, T-cell responses to AQP4 and myelin peptides were studied in 12 NM0 patients, 10 multiple sclerosis (MS) patients and 10 healthy subjects (HS). Four hours after adding 1 of 28 overlapping AQP4 peptides, a mixture of AQP4 peptides (AQP4-M) or one of six distinct myelin peptides to 2-day cultured PBMC, CD69 expression on CD4+ T cells was examined. Data were analyzed by paired t-test, frequency of samples with 3-fold increase of CD69 on CD4+ cells (fSI3) and mean stimulation index (mSI). The T-cell response to AQP4-M was significantly increased in NMO (fSI3 = 10/12, mSI = 5.50), with AQP4 (11-30) and AQP4 (91-110) representing the two major epitopes (AQP4 (11-30), fSI3 = 11/12, mSI = 16.0 and AQP4 (91-110), fSI3 = 11/12, mSI = 13.0). Significant but less extensive responses to these two epitopes were also observed in MS and HS. Significant reactivities against AQP4 (21-40), AQP4 (61-80), AQP4 (101-120), AQP4 (171-190) and AQP4 (211-230) were exclusively found in NMO. In addition, responses to AQP4 (81-100) were higher and more frequently detected in NMO, without reaching statistical significance. Interestingly, among the six myelin peptides studied, proteolipid protein (95-116) induced a significant T-cell response in NMO (fSI3 = 7/12, mSI = 4.60). Our study suggests that cellular as well as humoral responses to AQP4 are necessary for NMO development and that the immune response to myelin protein may contribute to disease pathogenesis.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"International Immunology, 23(9), pp.565-573; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"21795759","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/intimm/dxr056","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Japanese Society for Immunology. 2011. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com"},{"subitem_rights":"This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Immunology following peer review. The definitive publisher-authenticated version International Immunology, 23(9), pp.565-573; 2011 is available online at: http://intimm.oxfordjournals.org/content/23/9/565."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10730708","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09538178","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14602377","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuya, Nemu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komori, Mika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nomura, Kyouichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakane, Shunya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukudome, Takayasu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Hirofumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiraishi, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wandinger, Klaus-Peter"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Hidenori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Takayuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"IntImm23_565.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"IntImm23_565.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/14031/files/IntImm23_565.pdf"},"version_id":"c15348b5-a47e-4d25-82a8-9f0a44a683a1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aquaporin-4","subitem_subject_scheme":"Other"},{"subitem_subject":"CD69","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuromyelitis optica","subitem_subject_scheme":"Other"},{"subitem_subject":"Proteolipid protein","subitem_subject_scheme":"Other"},{"subitem_subject":"T cell","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica."}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-10-01"},"publish_date":"2012-10-01","publish_status":"0","recid":"14031","relation_version_is_last":true,"title":["Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:55:47.422348+00:00"}