{"created":"2023-05-15T16:40:00.527806+00:00","id":14099,"links":{},"metadata":{"_buckets":{"deposit":"fd3969c2-5de0-4899-b8bf-522b2401d473"},"_deposit":{"created_by":2,"id":"14099","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"14099"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00014099","sets":["8:9"]},"author_link":["50692","50691"],"item_2_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Antigen specific treatment for the inhibition and remission of type 1 diabetes"}]},"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"439","bibliographicPageStart":"432","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"日本臨床免疫学会会誌"},{"bibliographic_title":"Japanese Journal of Clinical Immunology","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年，抗CD3抗体などの生物学的製剤を中心に，ヒト1型糖尿病の分野においても，疾患の治癒・寛解を目指し治療法の開発研究がすすめられているが，安全性，経済性などの問題を抱えている．インスリンは，ヒト，NODマウスの1型糖尿病発症に関連した主要自己抗原である．膵島浸潤T細胞に反応せず，しかも，血糖降下作用を維持する変異インスリン（B鎖16位残基アラニン置換）のみを発現するNODマウスでは，インスリン自己抗体が発現せず，糖尿病も発症しない．NODマウスに，poly I:Cをアジュバントに，インスリンB鎖ペプチドを皮下投与すると，制御性T細胞だけでなく，攻撃側のeffector細胞も膵島内に誘導する．一方，インスリンB鎖16, 19位残基を置換したアナログペプチドを，コレラトキシンをアジュバントに経鼻投与すると，強力な糖尿病発症の抑制と高血糖からの寛解を誘導した．このように，膵島抗原を用いた免疫学的治療法は，投与ルートやアジュバント，補助療法に改良を加え，制御性T細胞を優位に誘導することより，今後，ヒト1型糖尿病において，安全な発症阻止，寛解誘導の治療法となる可能性がある．","subitem_description_type":"Abstract"},{"subitem_description":"Treatment with anti-CD3 antibodies appears promising to preserve residual beta-cell function in recent onset type 1 diabetes although many patients had therapy related adverse events. Insulin is an important islet antigen and autoimmunity to insulin may be central to disease pathogenesis of type 1 diabetes in man and NOD mouse. Evidence is strongest for the NOD mouse model, where blocking immune responses to insulin by amino acid substitution at positions B: 16, prevents diabetes. Insulin can be used to immunologically prevent diabetes of NOD mice, however, insulin-based preventive immunoregulation of diabetes in man is not yet possible. Treatment of NOD mice with insulin B-chain peptide and poly I: C, a Toll-like receptor 3 ligand, induces the pathogenic T cells as well as regulatory T cells and recruits them into the islets. Intranasal treatment with insulin B-chain analogue peptide with amino acid substitutions at positions B: 16 and 19 prevented the progression to diabetes and induced remission from hyperglycemia when co-administered with a mucosal adjuvant cholera toxin. Thus, an antigenic peptide vaccination with an alternative adjuvant or route might induce antigen-specific regulatory cell populations rather than pathogenic T cells. We believe that such an improved antigen specific therapy could provide more efficient and safer disease suppression and remission for human type 1 diabetes.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"日本臨床免疫学会会誌, 31(6), pp.432-439; 2008","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"50692","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Abiru, Norio"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本臨床免疫学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2177/jsci.31.432","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2008 日本臨床免疫学会"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00357971","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09114300","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13497413","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"The Japan Society for Clinical Immunology"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"阿比留, 教生"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"JJCI31_432.pdf","filesize":[{"value":"984.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JJCI31_432.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/14099/files/JJCI31_432.pdf"},"version_id":"1267fd06-0149-450f-9b1a-069e0b2dfebd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"type 1 diabetes","subitem_subject_scheme":"Other"},{"subitem_subject":"prevention","subitem_subject_scheme":"Other"},{"subitem_subject":"autoantigen","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"regulatory T cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"1型糖尿病の発症阻止と寛解誘導","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"1型糖尿病の発症阻止と寛解誘導"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-10-05"},"publish_date":"2010-10-05","publish_status":"0","recid":"14099","relation_version_is_last":true,"title":["1型糖尿病の発症阻止と寛解誘導"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:18:07.564081+00:00"}