@article{oai:nagasaki-u.repo.nii.ac.jp:00014474,
 author = {Eguchi, Susumu and Takatsuki, Mitsuhisa and Hidaka, Masaaki and Soyama, Akihiko and Muraoka, Izumi and Tomonaga, Tetsuo and Shimokawa, Isao and Kanematsu, Takashi},
 issue = {5},
 journal = {Digestive diseases and sciences},
 month = {May},
 note = {BACKGROUND: A grafted donor liver should grow and survive under the different conditions presented by a liver transplantation recipient. It has remained unclear, however, whether the age of a grafted liver can be modulated by recipient factors. AIMS: This study investigated whether a grafted aged donor liver can be rejuvenated in a pediatric recipient. METHODS: Of 119 living donor liver transplants, ten pairs were adult-to-pediatric combinations. Senescence marker protein-30 (SMP-30), which is a protein that is remarkably reduced upon aging, was used as a senescence marker. Immunohistochemical staining for SMP-30 was performed in biopsy specimen after living donor liver transplantation (LDLT). Re-expression of SMP-30 was investigated in a biopsied adult liver (n = 6) that had been transplanted in a pediatric recipient. RESULTS: A remarkable expression of SMP-30 was seen in a control pediatric normal liver in comparison with that in an aged adult donor biopsy. Re-expression or an increase in SMP-30 was not observed in the liver of any pediatric recipient who had received an adult liver. CONCLUSION: An adult grafted liver does not appear to rejuvenate in a pediatric recipient., Digestive diseases and sciences, 56(5), pp.1542-1547; 2011},
 pages = {1542--1547},
 title = {Lack of Grafted Liver Rejuvenation in Adult-to-Pediatric Liver Transplantation.},
 volume = {56},
 year = {2011}
}