{"created":"2023-05-15T16:40:16.588077+00:00","id":14474,"links":{},"metadata":{"_buckets":{"deposit":"a87f7744-dc50-4269-9684-9f078527d507"},"_deposit":{"created_by":2,"id":"14474","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"14474"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00014474","sets":["29:30"]},"author_link":["53053","53052","53054","53048","53051","53050","53049","53055"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1547","bibliographicPageStart":"1542","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"Digestive diseases and sciences"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND: A grafted donor liver should grow and survive under the different conditions presented by a liver transplantation recipient. It has remained unclear, however, whether the age of a grafted liver can be modulated by recipient factors. AIMS: This study investigated whether a grafted aged donor liver can be rejuvenated in a pediatric recipient. METHODS: Of 119 living donor liver transplants, ten pairs were adult-to-pediatric combinations. Senescence marker protein-30 (SMP-30), which is a protein that is remarkably reduced upon aging, was used as a senescence marker. Immunohistochemical staining for SMP-30 was performed in biopsy specimen after living donor liver transplantation (LDLT). Re-expression of SMP-30 was investigated in a biopsied adult liver (n = 6) that had been transplanted in a pediatric recipient. RESULTS: A remarkable expression of SMP-30 was seen in a control pediatric normal liver in comparison with that in an aged adult donor biopsy. Re-expression or an increase in SMP-30 was not observed in the liver of any pediatric recipient who had received an adult liver. CONCLUSION: An adult grafted liver does not appear to rejuvenate in a pediatric recipient.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Digestive diseases and sciences, 56(5), pp.1542-1547; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"20936349","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s10620-010-1445-5","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Springer Science+Business Media, LLC 2010"},{"subitem_rights":"The original publication is available at www.springerlink.com"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00161107","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01632116","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"15732568","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Eguchi, Susumu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takatsuki, Mitsuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hidaka, Masaaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Soyama, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muraoka, Izumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomonaga, Tetsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimokawa, Isao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanematsu, Takashi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"DDS56_1542.pdf","filesize":[{"value":"4.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DDS56_1542.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/14474/files/DDS56_1542.pdf"},"version_id":"720549cf-67c2-4f4f-b10c-350fac553b38"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Graft","subitem_subject_scheme":"Other"},{"subitem_subject":"Living donor liver transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"Pediatric","subitem_subject_scheme":"Other"},{"subitem_subject":"Rejuvenation","subitem_subject_scheme":"Other"},{"subitem_subject":"Senescence marker protein-30","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Lack of Grafted Liver Rejuvenation in Adult-to-Pediatric Liver Transplantation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Lack of Grafted Liver Rejuvenation in Adult-to-Pediatric Liver Transplantation."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-11-08"},"publish_date":"2010-11-08","publish_status":"0","recid":"14474","relation_version_is_last":true,"title":["Lack of Grafted Liver Rejuvenation in Adult-to-Pediatric Liver Transplantation."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T00:18:14.213749+00:00"}