@article{oai:nagasaki-u.repo.nii.ac.jp:00014555,
 author = {Nanashima, Atsushi and Takeshita, Hiroaki and Tobinaga, Syuuichi and Araki, Masato and Sumida, Yorihisa and Kunizaki, Masaki and Tanaka, Kenji and Abo, Takafumi and Hidaka, Shigekazu and Sawai, Terumitsu and Yasutake, Toru and Nagayasu, Takeshi},
 issue = {101},
 journal = {Hepato-Gastroenterology},
 month = {Jul},
 note = {Background/Aims: Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (1CTP) is a sensitive serum marker for metastatic bone carcinomas and may also be associated with invasiveness of various carcinomas. To clarify the significance of 1CTP in hepato-biliary pancreas malignancies, we examined the relationship between clinicopathological features and serum level of 1CTP. Methodology: The subjects were 75 patients who underwent surgical resections including 27 patients with liver carcinomas, 15 with extra-hepatic biliary carcinomas, 14 pancreatic carcinomas and 19 benign diseases. Results: 1CTP level tended to be higher in the malignant diseases than in benign diseases but this difference was not significant (p=0.065). Compared to benign adenoma, 1CTP level in the malignant diseases was significantly higher (p=0.049). 1CTP level tended to be higher in patients with cholangitis compared to those with no inflammation or benign tumors (p=0.065). 1CTP was not correlated with any tumor markers. 1CTP was not associated with node status and vascular infiltrations. 1CTP level tended to be lower in patients with poor differentiation. Conclusions: Serum level of 1CTP might be a predictive marker for hepatobiliary pancreas malignancies but also reflects the degree of co-existing cholangitis., Hepato-Gastroenterology, 57(101), pp.694-697; 2010},
 pages = {694--697},
 title = {Measurement of serum marker for bone metastasis (1-CTP) in hepatobiliary and pancreas malignancies},
 volume = {57},
 year = {2010}
}