@article{oai:nagasaki-u.repo.nii.ac.jp:00014565,
 author = {Hozumi, Akira and Osaki, Makoto and Sakamoto, Kazutaka and Goto, Hisataka and Fukushima, Tatsuya and Baba, Hideo and Shindo, Hiroyuki},
 issue = {5},
 journal = {Biomedical Research},
 month = {},
 note = {Several studies have demonstrated the association of plasminogen activator inhibitor-1 (PAI-1) with osteonecrosis, but the underlying mechanism of osteonecrosis and its relationship with local PAI-1 is not clear. The objective of this study was to evaluate PAI-1 production by primary human bone marrow adipocytes and the effects of glucocorticoid administration. Bone marrow was obtained from 25 individuals during prosthetic insertion. Mature adipocytes were cultured for 24 h with or without dexamethasone. PAI-1, adiponectin, tumor necrosing factor-α (TNFα) expression were measured by latex photometric immunoassay or RT-PCR. Adiponectin, TNFα and PAI-1 were detected in all culture media. PAI-1 expression was signiicantly increased by treatment with 10-6 mol/L dexamethasone up to 24 h in protein and mRNA levels, while the levels of other adipokines did not change by dexamethasone. These results suggest that bone marrow adipocytes may play important roles for the development of glucocorticoid-induced osteonecrotic diseases by enhancing PAI-1 expression., Biomedical Research, 31(5), pp.281-286; 2010},
 pages = {281--286},
 title = {Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes},
 volume = {31},
 year = {2010}
}