{"created":"2023-05-15T16:40:20.625240+00:00","id":14565,"links":{},"metadata":{"_buckets":{"deposit":"b396a385-4704-4e00-b69b-721b23903fc4"},"_deposit":{"created_by":2,"id":"14565","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"14565"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00014565","sets":["29:30"]},"author_link":["53555","53557","53551","53556","53554","53553","53552"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"286","bibliographicPageStart":"281","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Biomedical Research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Several studies have demonstrated the association of plasminogen activator inhibitor-1 (PAI-1) with osteonecrosis, but the underlying mechanism of osteonecrosis and its relationship with local PAI-1 is not clear. The objective of this study was to evaluate PAI-1 production by primary human bone marrow adipocytes and the effects of glucocorticoid administration. Bone marrow was obtained from 25 individuals during prosthetic insertion. Mature adipocytes were cultured for 24 h with or without dexamethasone. PAI-1, adiponectin, tumor necrosing factor-α (TNFα) expression were measured by latex photometric immunoassay or RT-PCR. Adiponectin, TNFα and PAI-1 were detected in all culture media. PAI-1 expression was signiicantly increased by treatment with 10-6 mol/L dexamethasone up to 24 h in protein and mRNA levels, while the levels of other adipokines did not change by dexamethasone. These results suggest that bone marrow adipocytes may play important roles for the development of glucocorticoid-induced osteonecrotic diseases by enhancing PAI-1 expression.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biomedical Research, 31(5), pp.281-286; 2010","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Biomedical Research Press"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2220/biomedres.31.281","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2010 Biomedical Research Press"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00110128","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03886107","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1880313X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hozumi, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osaki, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Kazutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Hisataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukushima, Tatsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Baba, Hideo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shindo, Hiroyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"BioRes31_281.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BioRes31_281.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/14565/files/BioRes31_281.pdf"},"version_id":"c69561f6-9000-48e5-930e-a5a33a63013a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-01-14"},"publish_date":"2011-01-14","publish_status":"0","recid":"14565","relation_version_is_last":true,"title":["Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:10:13.606553+00:00"}