{"created":"2023-05-15T16:40:21.641935+00:00","id":14589,"links":{},"metadata":{"_buckets":{"deposit":"cec2f21b-94b8-4e5c-a730-1965e99b966e"},"_deposit":{"created_by":2,"id":"14589","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"14589"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00014589","sets":["10:11"]},"author_link":["53741","53739","53740","53742"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-11-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"577","bibliographicPageStart":"573","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The previous data regarding the effect of irradiation on thyroid autoimmunity are controversial. We have recently reported the exacerbation of autoimmune thyroiditis by a single low dose (0.5 Gy) of whole body irradiation in thyroiditis-prone non-obese diabetic (NOD)-H2h4 mice treated with iodine for 8 weeks. However, it is uncertain in that report whether the results obtained by the provision of iodine in a relatively short period of time (8 weeks) accurately reflects the long-term consequences of low-dose irradiation on thyroid autoimmunity. Therefore, we repeated these experiments with mice that were monitored after irradiation without iodine treatment for up to 15 months. We found that a single low-dose (0.5 Gy) irradiation increased the incidence and severity of thyroiditis and the incidence and titers of anti-thyroglobulin autoantibodies at 15 months of age. The numbers of splenocytes and percentages of various lymphocyte subsets were not affected by irradiation. Thus, we conclude that low-dose irradiation also exacerbates late-onset spontaneous thyroiditis in NOD-H2h4 mice; one plausible explanation for this may be the acceleration of immunological aging by irradiation.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of radiation research, 50(6), pp.573-577; 2009","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本放射線影響学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1269/jrr.09067","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2009 by THE JAPAN RADIATION RESEARCH SOCIETY"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00705792","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04493060","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13499157","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"The Japan Radiation Research Society"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nagayama, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichikawa, Tatsuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saitoh, Ohki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abiru, Norio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"JRR50_573.pdf","filesize":[{"value":"94.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JRR50_573.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/14589/files/JRR50_573.pdf"},"version_id":"228a1412-5797-4b96-bb84-fd884c596ece"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Autoimmune thyroiditis","subitem_subject_scheme":"Other"},{"subitem_subject":"Iodine","subitem_subject_scheme":"Other"},{"subitem_subject":"Low-dose irradiation","subitem_subject_scheme":"Other"},{"subitem_subject":"NOD-H2 h4 mice","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Induction of Late-onset Spontaneous Autoimmune Thyroiditis by a Single Low-dose Irradiation in Thyroiditis-prone Non-obese Diabetic-H2h4 Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Induction of Late-onset Spontaneous Autoimmune Thyroiditis by a Single Low-dose Irradiation in Thyroiditis-prone Non-obese Diabetic-H2h4 Mice"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-01-26"},"publish_date":"2011-01-26","publish_status":"0","recid":"14589","relation_version_is_last":true,"title":["Induction of Late-onset Spontaneous Autoimmune Thyroiditis by a Single Low-dose Irradiation in Thyroiditis-prone Non-obese Diabetic-H2h4 Mice"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:01:16.587769+00:00"}