{"created":"2023-05-15T16:30:22.058157+00:00","id":1466,"links":{},"metadata":{"_buckets":{"deposit":"8fb50835-a74b-43bd-8f9d-96955a4d1b0a"},"_deposit":{"created_by":2,"id":"1466","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1466"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001466","sets":["8:9"]},"author_link":["6981","6982","6988","6983","6990","6987","6986","6989","6985","6980","6979","6984"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"57","bibliographicPageStart":"50","bibliographicVolumeNumber":"75","bibliographic_titles":[{"bibliographic_title":"Leukemia Research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Atypical chronic myeloid leukemia(aCML)and chronic neutrophilic leukemia(CNL)are rare BCR-ABL1 fusion gene-negative myeloid neoplasms with a predominance of neutrophils. \nSince no standard therapeutic strategy currently exists for these diseases,we retrospectively evaluated the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aCML and CNL. Data from 14 aCML and 5 CNL patients as their diagnoses were collected using a nationwide survey. Allo-HSCT was performed between 2003 and 2014. Preconditioning regimens included myeloablative (n = 15),reduced-intensity (n = 3), and non-myeloablative (n = 1) regimens. Transplanted stem cells were obtained from HLA-matched related donors (n = 5) and alternative donors (n = 14). Neutrophil engraftment was successfully achieved in 17 patients. One-year overall survival rates (OS) were 54.4% (95% confidence interval [CI], 24.8 to 76.7%) and 40.0% (95% CI, 5.2 to 75.3%) in patients with aCML and CNL, respectively. Among aCML patients, 1-year OS were 76.2% (95% CI, 33.2 to 93.5%) and 20.0% (95% CI, 0.8 to 58.2%) in patients with <5% myeloblasts (n = 9) and ?5% myeloblasts (n = 5) in peripheral blood before allo-HSCT, respectively. These results suggest that allo-HSCT achieves long-term survival in patients with aCML and CNL. \nBetter pre-transplant management is required to improve the outcomes of aCML patients with ?5% blasts in peripheral blood.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Leukemia Research, 75, pp.50-57; 2018","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.leukres.2018.11.003","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c2018, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01452126","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Itonaga, Hidehiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Shuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taji, Hirohumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Amano, Itsuto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Yuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichinohe, Tatsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Atsuta, Yoshiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanizawa, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Yasushi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"LR75_50.pdf","filesize":[{"value":"483.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"LR75_50.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1466/files/LR75_50.pdf"},"version_id":"e94bd2a0-ebf2-43e9-9681-b0309ba27fbc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Allogeneic hematopoietic stem cell transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"Atypical chronic myeloid leukemia","subitem_subject_scheme":"Other"},{"subitem_subject":"Chronic neutrophil leukemia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Allogeneic hematopoietic stem cell transplantation for the treatment of BCR-ABL1-negative atypical chronic myeloid leukemia and chronic neutrophil leukemia: A retrospective nationwide study in Japan","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Allogeneic hematopoietic stem cell transplantation for the treatment of BCR-ABL1-negative atypical chronic myeloid leukemia and chronic neutrophil leukemia: A retrospective nationwide study in Japan"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-01"},"publish_date":"2020-01-01","publish_status":"0","recid":"1466","relation_version_is_last":true,"title":["Allogeneic hematopoietic stem cell transplantation for the treatment of BCR-ABL1-negative atypical chronic myeloid leukemia and chronic neutrophil leukemia: A retrospective nationwide study in Japan"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:01:52.418816+00:00"}