@article{oai:nagasaki-u.repo.nii.ac.jp:00014825,
 author = {Hasegawa, H and Yamada, Yasuaki and Tsukasaki, Katsumi and Mori, N and Tsuruda, Kazuto and Sasaki, Daisuke and Usui, Tetsuya and Osaka, Akemi and Atogami, Sunao and Ishikawa, Chie and Machijima, Yoshiaki and Sawada, S and Hayashi, Tomayoshi and Miyazaki, Yasushi and Kamihira, Shimera},
 issue = {4},
 journal = {Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K},
 month = {Apr},
 note = {Adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), is resistant to treatment. In this study, we examined the effects of a new inhibitor of deacetylase enzymes, LBH589, on ATLL cells. LBH589 effectively induced apoptosis in ATLL-related cell lines and primary ATLL cells and reduced the size of tumors inoculated in SCID mice. Analyses, including with a DNA microarray, revealed that neither death receptors nor p53 pathways contributed to the apoptosis. Instead, LBH589 activated an intrinsic pathway through the activation of caspase-2. Furthermore, small interfering RNA experiments targeting caspase-2, caspase-9, RAIDD, p53-induced protein with a death domain (PIDD) and RIPK1 (RIP) indicated that activation of RAIDD is crucial and an event initiating this pathway. In addition, LBH589 caused a marked decrease in levels of factors involved in ATLL cell proliferation and invasion such as CCR4, IL-2R and HTLV-1 HBZ-SI, a spliced form of the HTLV-1 basic zipper factor HBZ. In conclusion, we showed that LBH589 is a strong inducer of apoptosis in ATLL cells and uncovered a novel apoptotic pathway initiated by activation of RAIDD.Leukemia advance online publication, 18 January 2011; doi:10.1038/leu.2010.315., This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/, Leukemia, 25(4), pp.575-578; 2011},
 pages = {575--578},
 title = {LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway.},
 volume = {25},
 year = {2011}
}