{"created":"2023-05-15T16:40:31.684259+00:00","id":14825,"links":{},"metadata":{"_buckets":{"deposit":"8f493b0e-84e5-42ae-b125-2a88e8cbe924"},"_deposit":{"created_by":2,"id":"14825","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"14825"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00014825","sets":["29:30"]},"author_link":["54399","54402","54403","54398","54400","54408","54407","54406","54401","54397","54409","54405","54404","54410","54411"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"578","bibliographicPageStart":"575","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), is resistant to treatment. In this study, we examined the effects of a new inhibitor of deacetylase enzymes, LBH589, on ATLL cells. LBH589 effectively induced apoptosis in ATLL-related cell lines and primary ATLL cells and reduced the size of tumors inoculated in SCID mice. Analyses, including with a DNA microarray, revealed that neither death receptors nor p53 pathways contributed to the apoptosis. Instead, LBH589 activated an intrinsic pathway through the activation of caspase-2. Furthermore, small interfering RNA experiments targeting caspase-2, caspase-9, RAIDD, p53-induced protein with a death domain (PIDD) and RIPK1 (RIP) indicated that activation of RAIDD is crucial and an event initiating this pathway. In addition, LBH589 caused a marked decrease in levels of factors involved in ATLL cell proliferation and invasion such as CCR4, IL-2R and HTLV-1 HBZ-SI, a spliced form of the HTLV-1 basic zipper factor HBZ. In conclusion, we showed that LBH589 is a strong inducer of apoptosis in ATLL cells and uncovered a novel apoptotic pathway initiated by activation of RAIDD.Leukemia advance online publication, 18 January 2011; doi:10.1038/leu.2010.315.","subitem_description_type":"Abstract"}]},"item_2_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/","subitem_description_type":"Other"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Leukemia, 25(4), pp.575-578; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"21242994","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/leu.2010.315","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2011 Macmillan Publishers Limited All rights reserved 0887-6924/11"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10668706","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"08876924","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14765551","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasegawa, H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Yasuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsukasaki, Katsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, N"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuruda, Kazuto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Usui, Tetsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osaka, Akemi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Atogami, Sunao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Chie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Machijima, Yoshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawada, S"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Tomayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamihira, Shimera"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"Leukemia25_575.pdf","filesize":[{"value":"880.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Leukemia25_575.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/14825/files/Leukemia25_575.pdf"},"version_id":"a38c2112-5456-4296-a35f-dc26d62944a6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-03-30"},"publish_date":"2011-03-30","publish_status":"0","recid":"14825","relation_version_is_last":true,"title":["LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:56:28.228957+00:00"}