@article{oai:nagasaki-u.repo.nii.ac.jp:00014845,
 author = {Taura, Naota and Ichikawa, Tatsuki and Miyaaki, Hisamitsu and Yatsuhashi, Hiroshi and Ishibashi, Hiromi and Nakao, Kazuhiko},
 issue = {1},
 journal = {Experimental and Therapeutic Medicine},
 month = {Jan},
 note = {The possibility has been raised in a number of cohort and case-control studies that diabetes mellitus (DM) may increase the risk of liver cancer, as well as that of cancer at other sites. To verify this possibility, we conducted a retrospective cohort study to determine the prevalence of type 2 DM in Japanese patients with hepatocellular carcinoma (HCC). Atotal of 1,251 patients with HCC, diagnosed at two major liver centers in the Nagasaki area, were consecutively recruited and categorized according to the etiology of HCC into four groups: HCC-B, HCC-C, HCC-BC and HCC-nonBC cases. Type 2 DM was diagnosed on the basis of standard criteria. The prevalence rate of HCC-nonBC and HCC-C was significantly higher than that of HCC-B, while the prevalence rate of HCC-nonBC was significantly higher than that of HCC-C. The prevalence of type 2 DM in HCC-B, HCC-Cand HCC-nonBC patients under 66 years of age was 11, 31 and 32%, respectively, vs. 24, 22 and 40%, respectively, in patients over 66 years of age. In patients over 66 years of age, the prevalence of type 2 DM in HCC-B and HCC-nonBC cases was increased, whereas the prevalence of type 2 DMin HCC-C cases was significantly decreased. Our findings indicate that the effects of the interaction between type 2 DM and HCV increase the prevalence of HCC., Experimental and Therapeutic Medicine, 2(1), pp.81-84; 2011},
 pages = {81--84},
 title = {Prevalence of type 2 diabetes mellitus in Japanese patients with hepatocellular carcinoma},
 volume = {2},
 year = {2011}
}