{"created":"2023-05-15T16:40:33.245272+00:00","id":14861,"links":{},"metadata":{"_buckets":{"deposit":"fcbc77bb-4173-46ce-8044-a1d8439e8bcf"},"_deposit":{"created_by":2,"id":"14861","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"14861"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00014861","sets":["8:9"]},"author_link":["54562","54572","54559","54563","54565","54573","54566","54571","54570","54569","54558","54561","54564","54560","54567","54568"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"448","bibliographicPageStart":"438","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"Apoptosis : an international journal on programmed cell death"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"C/EBP homologous protein (CHOP) has been proposed as a key transcription factor for endoplasmic reticulum (ER) stress-mediated β-cell death induced by inflammatory cytokines in vitro. However, the contribution of CHOP induction to the pathogenesis of type 1 diabetes is not yet clear. To evaluate the relevance of CHOP in the pathogenesis of type 1 diabetes in vivo, we generated CHOP-deficient non-obese diabetic (NOD.Chop (-/-)) mice. CHOP deficiency did not affect the development of insulitis and diabetes and apoptosis in β-cells. Interestingly, NOD.Chop (-/-) mice exhibited a delayed appearance of insulin autoantibodies compared to wild-type (wt) mice. Adoptive transfer with the diabetogenic, whole or CD8(+)-depleted splenocytes induced β-cell apoptosis and the rapid onset of diabetes in the irradiated NOD.Chop (-/-) recipients with similar kinetics as in wt mice. Expression of ER stress-associated genes was not significantly up-regulated in the islets from NOD.Chop (-/-) compared to those from wt mice or NOD-scid mice. These findings suggest that CHOP expression is independent of the development of insulitis and diabetes but might affect the early production of insulin autoantibodies in the NOD mouse.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Apoptosis, 16(4), pp.438-448; 2011","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"21274633","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s10495-011-0576-2","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Springer Science+Business Media, LLC 2011"},{"subitem_rights":"The original publication is available at www.springerlink.com"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11148723","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13608185","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1573675X","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Satoh, T"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abiru, Norio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, M"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhou, H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuriya, Genpei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagayama, Y"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawasaki, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamasaki, H"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yu, L"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eisenbarth, G S"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Araki, Eiichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, M"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oyadomari, Seiichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, K"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-22"}],"displaytype":"detail","filename":"Apoptosis16_438.pdf","filesize":[{"value":"805.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Apoptosis16_438.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/14861/files/Apoptosis16_438.pdf"},"version_id":"9857ca3d-5a16-431e-a267-baa492af0a83"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Autoantibody","subitem_subject_scheme":"Other"},{"subitem_subject":"CHOP","subitem_subject_scheme":"Other"},{"subitem_subject":"ER stress","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-obese diabetic mouse","subitem_subject_scheme":"Other"},{"subitem_subject":"Type 1 diabetes","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse."}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-04-07"},"publish_date":"2011-04-07","publish_status":"0","recid":"14861","relation_version_is_last":true,"title":["CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T18:50:24.304984+00:00"}