@article{oai:nagasaki-u.repo.nii.ac.jp:00014961,
 author = {Okumura, Teruhito and Gonda, Yoshinori and Ioku, Koji and Kamitakahara, Masanobu and Okuda, Takatoshi and Yonezawa, Ikuho and Kurosawa, Hisashi and Asahina, Izumi and Ikeda, Tohru},
 issue = {1386},
 journal = {Journal of the Ceramic Society of Japan},
 month = {Feb},
 note = {Porous spherical granules of β-tricalcium phosphate (β3-TCP) composed of rod-shaped particles were prepared viaa hydrothermal route. The biological significance ofimplantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created intibiae of 9-week-oldWistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residualimplants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer intibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted granules worked as scaffolds to maintainalkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow., Journal of the Ceramic Society of Japan, 119(1386), pp.101-104; 2011},
 pages = {101--104},
 title = {Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia},
 volume = {119},
 year = {2011}
}