@article{oai:nagasaki-u.repo.nii.ac.jp:00001498, author = {Fujita, Yuya and Fukui, Shoichi and Suzuki, Takahisa and Ishida, Midori and Endo, Yushiro and Tsuji, Sousuke and Takatani, Ayuko and Igawa, Takashi and Shimizu, Toshimasa and Umeda, Masataka and Sumiyoshi, Remi and Nishino, Ayako and Koga, Tomohiro and Kawashiri, Shin-ya and Iwamoto, Naoki and Ichinose, Kunihiro and Tamai, Mami and Nakamura, Hideki and Origuchi, Tomoki and Abe, Kuniko and Kawakami, Atsushi}, issue = {23}, journal = {Internal Medicine}, month = {Jul}, note = {A 56-year-old Japanese woman with muscle weakness, increased creatine kinase and aldolase levels, and characteristic cutaneous lesions was diagnosed with anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 antibody)-positive dermatomyositis. She also had interstitial lung disease (ILD). After corticosteroid and tacrolimus combination therapy was started, bicytopenia and elevated serum ferritin and trans-aminase emerged. Because the bone marrow tissues were hypoplastic with hemophagocytes, she was diagnosed with concomitant autoimmune-associated hemophagocytic syndrome (HPS). Intravenous cyclophosphamide pulse therapy and plasmapheresis were performed. The laboratory findings indicated improved abnormalities, and the ILD did not progress. Anti-MDA5 antibody-positive dermatomyositis can be complicated by HPS., Internal Medicine, 57(23), pp.3473-3478; 2018}, pages = {3473--3478}, title = {Anti-MDA5 Antibody-positive Dermatomyositis Complicated by Autoimmune-associated Hemophagocytic Syndrome That Was Successfully Treated with Immunosuppressive Therapy and Plasmapheresis}, volume = {57}, year = {2018} }