{"created":"2023-05-15T16:30:23.757178+00:00","id":1505,"links":{},"metadata":{"_buckets":{"deposit":"245fe628-7d0a-4b4b-bdda-d4b801e8e6bf"},"_deposit":{"created_by":2,"id":"1505","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1505"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001505","sets":["10:11"]},"author_link":["7179","7177","7176","7187","7191","7178","7183","7185","7181","7186","7188","7189","7180","7190","7184","7182"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12-14","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"277","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Arthritis Research & Therapy"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The aim of this study was to identify fibrosis-related serological surrogate outcome measures in patients with immunoglobulin G4-related disease (IgG4-RD). Methods: This was a clinical observational study of 72 patients with untreated IgG4-RD from four institutions in Japan.The serum concentrations of growth differentiation factor 15 (GDF-15), CCL2, hyaluronic acid (HA), amino-terminal propeptide of type III procollagen (PIIINP), and tissue inhibitor of metalloproteinases 1 (TIMP-1) were measured by enzyme-linked immunosorbent assays. The enhanced liver fibrosis (ELF) score was calculated from the TIMP-1, PIIINP, and HA values. We evaluated associations between the values of these biomarkers and laboratory data, the IgG4-RD responder index (IgG4-RD RI) score, and organ involvements. Results: Compared with the 44 healthy controls, the patients with IgG4-RD showed significantly elevated serum concentrations of GDF-15, MCP-1, HA, PIIINP, \nand TIMP-1 and ELF scores. The patients' serum concentrations of GDF-15, CCL2, \nHA, and TIMP-1 (but not PIIINP) were positively correlated with each other. Among them, serum GDF-15 most efficiently distinguished patients with IgG4-RD from healthy controls. Serum GDF-15 was not associated with the IgG4-RD RI score or the number of organ involvements but was independently associated with the presence of retroperitoneal fibrosis and with parotid gland involvement. Conclusions: We observed increased serological surrogate outcome measures of fibrosis in IgG4-RD. GDF-15 may precisely reflect the fibrotic degree in patients with IgG4-RD.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Arthritis Research and Therapy, 20(1), art.no.277; 2018","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s13075-018-1777-7","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"cThe Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14786362","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawashiri, Shin-ya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Origuchi, Tomoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umeda, Masataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishino, Ayako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Toshimasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukui, Shoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koga, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwamoto, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichinose, Kunihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamai, Mami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawano, Mitsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Motohisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izumi, Yasumori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Atsushi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"ART20_277.pdf","filesize":[{"value":"882.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ART20_277.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1505/files/ART20_277.pdf"},"version_id":"95920a75-8715-4373-a203-8ca22ca4b7fc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IgG4-related disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibrosis","subitem_subject_scheme":"Other"},{"subitem_subject":"GDF-15 organ involvement","subitem_subject_scheme":"Other"},{"subitem_subject":"Prednisolone","subitem_subject_scheme":"Other"},{"subitem_subject":"Responder index","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-17"},"publish_date":"2019-01-17","publish_status":"0","recid":"1505","relation_version_is_last":true,"title":["Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:01:16.405742+00:00"}