{"created":"2023-05-15T16:40:45.949580+00:00","id":15154,"links":{},"metadata":{"_buckets":{"deposit":"5cbe7613-7c09-4da2-b5be-b6ab052276eb"},"_deposit":{"created_by":2,"id":"15154","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"15154"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00015154","sets":["29:30"]},"author_link":["55706","55704","55702","55703","55697","55698","55701","55705","55700","55699"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"94-95","bibliographicPageEnd":"1470","bibliographicPageStart":"1466","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"Hepato-gastroenterology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND/AIMS: The aim of this study was to regenerate transplanted hepatocytes selectively in a recipient using retrorsine and recombinant human hepatocyte growth factor (rhHGF). METHODOLOGY: Nagase analbuminemic rats (NARs) received pretreatment with retrosine and were divided into three experimental groups. Group1: Hepatocyte transplantation (HcTx) + 50 microg/kg/day rhHGF. Group2: HcTx + 250 microg/kg/day rhHGF. Group3: HcTx + normal saline. The serum levels of albumin and the albumin-positive hepatocytes in the liver were investigated. The rat endogenous HGF of the rats given only retrorsine was measured. RESULTS: The serum albumin levels of Group11 were higher than those of Group2, while there was no significant difference between Group2 and GroupS. Histological examination of Group1 and 3 showed the presence of a large number of albumin-positive hepatocytes, which frequently consisted of large clusters and occupied 53.90 +/- 2.31% and 31.25 +/- 5.36% of host liver, respectively. The liver sections of Group2 showed numerous albumin-positive hepatocyte, which were not seen as clusters. The rat endogenous HGF concentration was extremely high. CONCLUSION: Low-dose rhHGF enhances the effect of HcTx under the suppressive state of proliferation of host hepatocytes. Because of the high endogenous HGF, the administration of a high concentration of rhHGF suppressed the regenerative activity of the transplanted hepatocytes.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Hepato-gastroenterology, 56(94-95), pp.1466-1470; 2009","subitem_description_type":"Other"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19950811","subitem_relation_type_select":"PMID"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© H.G.E. Update Medical Publishing S.A."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00213244","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01726390","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hamada, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Susumu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takatsuki, Mitsuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamanouchi, Kosho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugiyama, Nozomu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashita, Yujo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okudaira, Sadayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tajima, Yoshitsugu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishii, Takehisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanematsu, Takashi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"HepGas56_1466.pdf","filesize":[{"value":"218.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HepGas56_1466.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/15154/files/HepGas56_1466.pdf"},"version_id":"e1fe6a6c-33de-464e-a5a8-e3c0f6453daf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hepatocyte growth factor","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatocyte transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"Regeneration","subitem_subject_scheme":"Other"},{"subitem_subject":"Retrorsine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Low-dose recombinant human hepatocyte growth factor enhances effect of hepatocyte transplantation in rats treated with retrorsine.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Low-dose recombinant human hepatocyte growth factor enhances effect of hepatocyte transplantation in rats treated with retrorsine."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-10-01"},"publish_date":"2010-10-01","publish_status":"0","recid":"15154","relation_version_is_last":true,"title":["Low-dose recombinant human hepatocyte growth factor enhances effect of hepatocyte transplantation in rats treated with retrorsine."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T00:11:16.758453+00:00"}