{"created":"2023-05-15T16:40:46.120526+00:00","id":15158,"links":{},"metadata":{"_buckets":{"deposit":"35249bbc-1ed9-43fd-85b2-09e6fd722f3a"},"_deposit":{"created_by":2,"id":"15158","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"15158"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00015158","sets":["8:9"]},"author_link":["55726","55729","55723","55725","55730","55733","55728","55731","55722","55727","55732","55721","55724"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"952","bibliographicPageStart":"947","bibliographicVolumeNumber":"94","bibliographic_titles":[{"bibliographic_title":"The Journal of clinical endocrinology and metabolism"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CONTEXT/OBJECTIVE: The IL-2 receptor-alpha (IL2RA), also known as CD25, is expressed on the regulatory T cells, which play an important role in the control of immune responses and the maintenance of immune homeostasis. Our objective was to determine whether variants in the IL2RA gene are associated with type 1 diabetes in the Japanese population. DESIGN/PATIENTS: We genotyped the four single-nucleotide polymorphisms (rs706778, rs3118470, ss52580101, and rs11594656) of the IL2RA in 885 patients with type 1 diabetes and 606 control subjects of Japanese origin. The allele and genotype frequencies were examined in the patient groups stratified by their mode of onset in a case-control study. RESULTS: We found evidence of association with acute-onset, but not slow-onset and fulminant, type 1 diabetes for two of the four single-nucleotide polymorphisms genotyped (rs706778 and rs3118470). The rs706778 A allele and the rs3118470 G allele were associated with an increased disease risk [odds ratio (OR) for rs706778 AA genotype 1.54, P = 4.2 x 10(-4) and OR for rs3118470 GG genotype 1.50, P = 0.0019, respectively]. Furthermore, the A-G haplotype was associated with increased type 1 diabetes risk in the acute-onset form (OR 1.30, P = 0.002). CONCLUSIONS: The present data confirm the type 1 diabetes association with IL2RA and provide evidence that the different contributions of the IL2RA in the susceptibility to acute-onset and other forms of type 1 diabetes in the Japanese population.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"The Journal of clinical endocrinology and metabolism, 94(3), pp.947-952; 2009","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Endocrine Society"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19106270","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1210/jc.2008-1596","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2009 by The Endocrine Society"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00695484","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021972X","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"19457197","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawasaki, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Awata, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikegami, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Tetsuro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maruyama, Taro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakanishi, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uga, Miho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurihara, Susumu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawabata, Yumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Shoichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanazawa, Yasuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Katsumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"JCEM94_947.pdf","filesize":[{"value":"160.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCEM94_947.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/15158/files/JCEM94_947.pdf"},"version_id":"17a9b405-e811-429b-b7c0-f75f94c2d65f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IL2RA","subitem_subject_scheme":"Other"},{"subitem_subject":"Genetics","subitem_subject_scheme":"Other"},{"subitem_subject":"Japanese","subitem_subject_scheme":"Other"},{"subitem_subject":"Type 1 diabetes","subitem_subject_scheme":"Other"},{"subitem_subject":"Mode of onset","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA","subitem_subject_scheme":"Other"},{"subitem_subject":"CTLA4","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population."}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-04-05"},"publish_date":"2010-04-05","publish_status":"0","recid":"15158","relation_version_is_last":true,"title":["Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:24:17.264040+00:00"}