@article{oai:nagasaki-u.repo.nii.ac.jp:00015205,
 author = {Hiu, Takeshi and Tsutsumi, Keisuke and Kitagawa, Naoki and Hayashi, Kentaro and Ujifuku, Kenta and Yasunaga, Akio and Suyama, Kazuhiko and Nagata, Izumi},
 issue = {2},
 journal = {Clinical neurology and neurosurgery},
 month = {Feb},
 note = {We herein report the first case of progressive perianeurysmal edema preceding the rupture of a small saccular aneurysm, without any intervention or intraluminal thrombosis. A 71-year-old woman was incidentally noted to have a cerebral aneurysm (5mm in diameter) at the lower basilar artery. Twelve months later, magnetic resonance (MR) imaging showed a T2-elongated area around a dome of the aneurysm buried in the brain stem, suggesting perianeurysmal edema formation. Interestingly, the edema progressed with the formation of a bleb, in addition to an increase in size of the aneurysm over the following 3-year period. The aneurysm eventually ruptured as a brain stem hemorrhage without any subarachnoid clots 3 days after the final check-up with MR imaging, by which a significant increase of edema formation with an increase in size of the aneurysm and a marked expansion of the bleb was observed. These findings raise the possibility that bleb formation and an enlargement of a small cerebral aneurysm might also be associated with perianeurysmal edema and a subsequent aneurysmal rupture. In addition to the pulsatile flow and/or compression from the expanded aneurysm, local inflammation in the aneurysm wall may play an important role in such edema formation., Clinical neurology and neurosurgery, 111(2), pp.216-219; 2009},
 pages = {216--219},
 title = {Progressive perianeurysmal edema preceding the rupture of a small basilar artery aneurysm.},
 volume = {111},
 year = {2009}
}