@article{oai:nagasaki-u.repo.nii.ac.jp:00015298,
 author = {Akahoshi, Hiroshi and Taura, Naota and Ichikawa, Tatsuki and Miyaaki, Hisamitsu and Akiyama, Motohisa and Miuma, Satoshi and Ozawa, Eisuke and Takeshita, Shigeyuki and Muraoka, Toru and Matsuzaki, Toshihisa and Ohtani, Masashi and Isomoto, Hajime and Matsumoto, Takehiro and Takeshima, Fuminao and Nakao, Kazuhiko},
 issue = {5},
 journal = {Oncology Reports},
 month = {May},
 note = {The number and ratio of both HBsAg- and HCV Abnegative hepatocellular carcinoma (HCC-nonBC) cases have been steadily increasing in Japan. The aim of this study was to examine the frequency of detection of HCC-nonBC by screening methods and to elucidate the clinical characteristics of HCC-nonBC compared with those of hepatitis C and/or B virus-associated HCC (HCC-virus). We recruited 624 patients with HCC who were diagnosed between 1982 and 2007 at the Department of Gastroenterology and Hepatology, Nagasaki University Hospital. They were categorized into 2 groups as follows: i) 550 were included in the HCC-virus group: positive for HBsAg and/or positive for HCV Ab, and ii) 74 were included in the HCC-nonBC group: negative for both HBsAg and HCV Ab. The follow-up patterns until the initial detection of HCC and the survival rates were analyzed and compared between the 2 groups. Multivariate analysis identified follow-up, alcohol consumption, albumin level, total bilirubin level, α-fetoprotein (AFP) level, and tumor-node-metastasis (TNM) stage as independent and significant risk factors for prognosis. Among the 397 patients with HCC in TNM stage I or II, multivariate analysis identified the cause of liver disease, gender, Child-Pugh score, serum albumin level and TNM stage as independent and significant risk factors for prognosis. We reported that the poor prognoses of patients with HCC-nonBC were attributable to its late detection in an advanced condition due to the absence of a surveillance system for the early detection of HCC. However, in early-stage patients, patients with HCC-nonBC showed significantly better prognosis than those in the HCC-virus group., Oncology Reports, 23(5), pp.1317-1323; 2010},
 pages = {1317--1323},
 title = {Differences in prognostic factors according to viral status in patients with hepatocellular carcinoma},
 volume = {23},
 year = {2010}
}