{"created":"2023-05-15T16:30:25.094102+00:00","id":1536,"links":{},"metadata":{"_buckets":{"deposit":"2e05b1cd-a460-4915-ae6e-fbab77a76b48"},"_deposit":{"created_by":2,"id":"1536","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1536"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001536","sets":["10:11"]},"author_link":["7369","7366","7368","7364","7367","7370","7365"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"673","bibliographicPageStart":"668","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Journal of Drug Delivery Science and Technology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We developed high functionality and quality (HFQ) lipids for facile and rapid preparation of ligand-grafted PEGylated liposomes.Because HFQ lipids are designed to exhibit good water dispersibility, ligand-grafted PEGylated liposomes can be easily prepared using the post-insertion method. The aim of this study is to develop novel VTWTPQAWFQWV (VTW) peptide-HFQ lipid \nto target human glioma cells. In order to disperse in water, VTW-(SG)5-lipid derivatives containing various amino acid residues with different charges were synthesized. Based on our previous work, (SG)5, a serine-glycine repeated peptide\n with a discrete molecular weight, was used as a spacer between the VTW and lipid. Of the derivatives tested, VTW-K3-(SG)5-lipid with three lysine residues showed the highest dispersibility in water,and VTW-K3-(SG)5/PEGylated liposomes can be prepared using the post-insertion method. The sizes of PEGylated liposomes and VTW-K3-(SG)5/PEGylated liposomes were 69.5 ± 4.4 and 74.4 ± 5.0 nm, respectively.In addition, the zeta potentials of PEGylated liposomes and VTW-K3-(SG)5/PEGylated liposomes were ?2.7 ± 1.6 and ?1.3 ± 0.3 mV, respectively. We found that VTW-K3-(SG)5/PEGylated liposomes selectively associated with human glioma U251MG cells.We succeeded in developing water-dispersible VTW-K3-(SG)5-lipids for the preparation of VTW-grafted PEGylated liposomes for glioma cell targeting.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Drug Delivery Science and Technology, 49, pp.668-673; 2019","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jddst.2018.12.037","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c2019 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"17732247","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suga, Tadaharu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Masanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugimoto, Yuri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuda, Tomonari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuroda, Naotaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hagimori, Masayori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Shigeru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"JDDST49_668.pdf","filesize":[{"value":"432.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JDDST49_668.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1536/files/JDDST49_668.pdf"},"version_id":"706c7877-660d-46ee-886c-c4c6511da3d4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"liposomes","subitem_subject_scheme":"Other"},{"subitem_subject":"targeting","subitem_subject_scheme":"Other"},{"subitem_subject":"PEG","subitem_subject_scheme":"Other"},{"subitem_subject":"hydrophobic peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"glioma","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis of a high functionality and quality lipid with gp130 binding hydrophobic peptide for the preparation of human glioma cell-targeted PEGylated liposomes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of a high functionality and quality lipid with gp130 binding hydrophobic peptide for the preparation of human glioma cell-targeted PEGylated liposomes"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-01"},"publish_date":"2020-03-01","publish_status":"0","recid":"1536","relation_version_is_last":true,"title":["Synthesis of a high functionality and quality lipid with gp130 binding hydrophobic peptide for the preparation of human glioma cell-targeted PEGylated liposomes"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:00:45.723737+00:00"}