{"created":"2023-05-15T16:41:03.108898+00:00","id":15555,"links":{},"metadata":{"_buckets":{"deposit":"0df14594-3af8-404a-939c-582df9be70c3"},"_deposit":{"created_by":2,"id":"15555","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"15555"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00015555","sets":["29:30"]},"author_link":["57592","57591","57593","57587","57588","57589","57590"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"481","bibliographicPageStart":"472","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Cell biology international"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The mechanism of maternal mitochondrial inheritance in animals involves the selective elimination of sperm mitochondria by the elimination factor of the egg and the sperm mitochondria-specific factor. In vitro fertilization using sperm from isogenic mice incorporating heterospecific mitochondrial DNA (mtDNA) showed that the number of PCR positives of sperm mtDNA in two-cell embryos was significantly increased following sperm incubation with anti-tetratricopeptide repeat-containing protein involved in spermatogenesis (tpis) protein, anti-translocator of mitochondrial outer membrane (Tom) 22 and anti-Tom40 antibodies. The treatment of fertilized eggs with EGTA and other endonuclease inhibitors increased the sperm mtDNA levels. We conclude that the elimination factor, which is probably an endonuclease, is selectively received by the tpis protein of the sperm mitochondrial outer membrane within the egg. It is then transported into the sperm mitochondria by Tom22 and Tom40, where it destroys the sperm mtDNA, establishing the maternal inheritance of mtDNA.","subitem_description_type":"Abstract"}]},"item_2_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"The Version of Record (VoR) is available at http://www.cellbiolint.org","subitem_description_type":"Other"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cell biology international, 29(6), pp.472-481; 2005","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Federation for Cell Biology"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"15979907","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.cellbi.2004.09.016","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2005 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10882014","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10656995","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hayashida, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Omagari, Katsuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuda, Jun-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hazama, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadokawa, Yoshiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohba, Kazuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohno, Shigeru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"CBI29_472.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CBI29_472.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/15555/files/CBI29_472.pdf"},"version_id":"ae792d45-2290-457b-828a-2430a355e295"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Elimination factor","subitem_subject_scheme":"Other"},{"subitem_subject":"Maternal mitochondrial inheritance","subitem_subject_scheme":"Other"},{"subitem_subject":"Sperm factor","subitem_subject_scheme":"Other"},{"subitem_subject":"Tom complex","subitem_subject_scheme":"Other"},{"subitem_subject":"tpis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The sperm mitochondria-specific translocator has a key role in maternal mitochondrial inheritance.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The sperm mitochondria-specific translocator has a key role in maternal mitochondrial inheritance."}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-09"},"publish_date":"2010-08-09","publish_status":"0","recid":"15555","relation_version_is_last":true,"title":["The sperm mitochondria-specific translocator has a key role in maternal mitochondrial inheritance."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-17T21:14:22.590934+00:00"}