{"created":"2023-05-15T16:41:08.310746+00:00","id":15669,"links":{},"metadata":{"_buckets":{"deposit":"2d99cb39-c3d6-43f5-9e4c-93f6362bd0e7"},"_deposit":{"created_by":2,"id":"15669","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"15669"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00015669","sets":["10:11"]},"author_link":["58311","58310"],"item_2_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Regulatory B cells"}]},"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"141","bibliographicPageStart":"135","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"日本臨床免疫学会会誌"},{"bibliographic_title":"Japanese Journal of Clinical Immunology","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"B細胞は抗体産生やT細胞活性化を通じて免疫反応に関与していることは知られていたが，近年になり炎症反応を制御するB細胞が存在することが明らかになった．T細胞の活性化を司るエフェクターB細胞に対して，この免疫を抑制するB細胞はレギュラトリーB細胞と呼ばれている．筆者らは，マウスの脾臓にIL-10産生B細胞が存在することを確認し，これらがCD1dhiCD5+の表現型を有していることを発見した．またアレルギー性接触皮膚炎のモデルである接触過敏反応において，このB細胞がIL-10依存性に炎症を抑制することを明らかにした．さらに多発性硬化症の早期にはレギュラトリーB細胞が優位に働くが，進行するにしたがいエフェクターB細胞が優位に働くことが明らかになった．このようにエフェクターB細胞とレギュラトリーB細胞のバランスが炎症や自己免疫の病態形成に重要であると考えられる．ヒトにおいてもレギュラトリーB細胞の存在が示唆されており，将来さまざまな炎症性疾患や自己免疫疾患などの治療に応用できる可能性がある.","subitem_description_type":"Abstract"},{"subitem_description":"B cells positively regulate immune responses through antibody production and optimal CD4+ T cell activation. However, a specific and functionally important subset of B cells can also negatively regulate immune responses in mouse autoimmunity and inflammation models. The lack or loss of regulatory B cells has been demonstrated by exacerbated symptoms in experimental autoimmune encephalitis, chronic colitis, contact hypersensitivity, collagen-induced arthritis, and non-obese diabetic mouse models. We have recently found that IL-10-producing regulatory B cells predominantly localize within a rare CD1dhiCD5+ B cell subset that shares cell surface markers with both B-1 and marginal zone B cells. We have labeled this specific-subset of regulatory B cells as B10 cells to highlight that these rare CD1dhiCD5+ B cells only produce IL-10 and are responsible for most IL-10 production by B cells, and to distinguish them from other regulatory B cell subsets that may also exist. This review focuses on the recent progress in this field and the exciting opportunities for understanding how this unique B cell subset influences diverse immune functions.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"日本臨床免疫学会会誌, 32(3), pp.135-141; 2009","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"58311","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yanaba, Koichi"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本臨床免疫学会"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"19564709","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2177/jsci.32.135","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2009 The Japan Society for Clinical Immunology."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00357971","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09114300","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13497413","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"The Japan Society for Clinical Immunology"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"簗場, 広一"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"JJCI32_135.pdf","filesize":[{"value":"829.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JJCI32_135.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/15669/files/JJCI32_135.pdf"},"version_id":"60a9d8ae-ec35-4a04-b2f1-63c3faa13e73"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Autoimmunity","subitem_subject_scheme":"Other"},{"subitem_subject":"B lymphocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-10","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"レギュラトリーB細胞","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"レギュラトリーB細胞"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-23"},"publish_date":"2010-08-23","publish_status":"0","recid":"15669","relation_version_is_last":true,"title":["レギュラトリーB細胞"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:18:08.317907+00:00"}