{"created":"2023-05-15T16:30:26.421612+00:00","id":1567,"links":{},"metadata":{"_buckets":{"deposit":"d39bab1e-a386-4571-961d-878068f57966"},"_deposit":{"created_by":2,"id":"1567","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1567"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001567","sets":["73:74"]},"author_link":["7531","7534","7532","7533","7535"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-01-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"825","bibliographicPageStart":"823","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Biological & Pharmaceutical Bulletin"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The hybrid of poly (ethylene glycol) and [D-Ala2] Leu-enkephalin was prepared by the solution method and its antinociceptive effect and inhibitory effect on the electrically induced contractions of mouse vas deferens were examined. The hybrid was synthesized by the coupling of Boc-Tyr-D-Ala-Gly-Phe-Leu-OH and amino-poly (ethylene glycol), followed by trifluoroacetic acid treatment. The hybrid showed more potent antinociceptive activity in mice and 120 times higher inhibitory activity in mouse vas deferens preparation than intact [D-Ala2] Leu-enkephalin.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biological & Pharmaceutical Bulletin, 17(6), pp.823-825; 1994","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/bpb.17.823","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c The Pharmaceutical Society of Japan"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09186158","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13475215","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Pharmaceutical Society of Japan"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MAEDA, Mitsuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWASAKI, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MAYUMI, Tadanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAHASHI, Masakatsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KANETO, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"BPB17_823.pdf","filesize":[{"value":"558.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BPB17_823.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1567/files/BPB17_823.pdf"},"version_id":"39dc1e74-a533-4ea5-a08e-d9be1093025f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"enkephalin hybrid","subitem_subject_scheme":"Other"},{"subitem_subject":"antinociceptive effect","subitem_subject_scheme":"Other"},{"subitem_subject":"poly (ethylene glycol) hybrid","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse vas deferens","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Amino Acids and Peptides. XXII. Preparation and Antinociceptive Effect of (D-Ala2)Leu-Enkephalin-Poly(Ethylene Glycol) Hybrid.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Amino Acids and Peptides. XXII. Preparation and Antinociceptive Effect of (D-Ala2)Leu-Enkephalin-Poly(Ethylene Glycol) Hybrid."}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-21"},"publish_date":"2019-02-21","publish_status":"0","recid":"1567","relation_version_is_last":true,"title":["Amino Acids and Peptides. XXII. Preparation and Antinociceptive Effect of (D-Ala2)Leu-Enkephalin-Poly(Ethylene Glycol) Hybrid."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:00:14.660996+00:00"}