{"created":"2023-05-15T16:30:26.505301+00:00","id":1569,"links":{},"metadata":{"_buckets":{"deposit":"274528e8-b067-49b7-9eac-543c2c89f0ab"},"_deposit":{"created_by":2,"id":"1569","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1569"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001569","sets":["73:74"]},"author_link":["7541","7540","7542","7543"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-03-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"479","bibliographicPageStart":"477","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"Biological & Pharmaceutical Bulletin"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Using various routes of administration, the antinociceptive effects of dihydroetorphine (DHE) and morphine were measured in mice. Regardless of the route of systemic and local administration, DHE (1-20μg/kg, i.p. ; 1-10μg/kg, s.c. ; 1-10μg/kg, i.v. ; 10-1000μg/kg, p.o. ; 10-100ng/mouse, intracerebroventricularly (i.c.v.) ; and 10-100ng/mouse, intrathecally (i.t.)) and morphine (1-20mg/kg, i.p. ; 1-10mg/kg, s.c. ; 1-10mg/kg, i.v. ; 10-100mg/kg, p.o. ; 1-10μg/mouse, i.c.v. ; and 0.5-3μg/mouse, i.t.) produced an antinociceptive effect in a dose-dependent manner, as evaluated by the tail pinch method. However, the duration of the antinociceptive effect of DHE was shorter than that of morphine. The efficacy ratio of the antinociceptive effect between DHE and morphine was approximately 1000 to 1500 : 1 by parenteral administration (i.p., s.c., or i.v.) and about 100 : 1 by the oral route. Meanwhile, using direct application into the central nervous system (CNS) (i.c.v. or i.t.), the effect of DHE was only 10 to 20 times that of morphine. These data suggest that DHE has an ideal quality as an analgesic by systemic administration which is a more convenient application than local injection, since only a minimum dose of DHE is needed to induce suitable potency of antinociception, and the duration of the effect is short. Further, these unique characteristics of DHE might lead to the prevention of the development of dependence by avoiding accumulation of the drug in the CNS.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biological & Pharmaceutical Bulletin, 19(3), pp.477-479; 1996","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/bpb.19.477","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c The Pharmaceutical Society of Japan"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09186158","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13475215","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Pharmaceutical Society of Japan"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TOKUYAMA, Shogo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAMURA, Fumihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAHASHI, Masakatsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KANETO, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"BPB19_477.pdf","filesize":[{"value":"563.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BPB19_477.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1569/files/BPB19_477.pdf"},"version_id":"5e2ede4e-4898-495c-bb4e-ec956e43a2fc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dihydroetorphine (DHE)","subitem_subject_scheme":"Other"},{"subitem_subject":"morphine","subitem_subject_scheme":"Other"},{"subitem_subject":"antinociception","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antinociceptive Effect of Dihydroetorphine Following Various Routes of Administration: a Comparative Study with Morphine.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antinociceptive Effect of Dihydroetorphine Following Various Routes of Administration: a Comparative Study with Morphine."}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-21"},"publish_date":"2019-02-21","publish_status":"0","recid":"1569","relation_version_is_last":true,"title":["Antinociceptive Effect of Dihydroetorphine Following Various Routes of Administration: a Comparative Study with Morphine."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:00:11.642522+00:00"}