@article{oai:nagasaki-u.repo.nii.ac.jp:00015750,
 author = {Yamanaka, Hitoki and Hoyt, Teri and Yang, Xinghong and Bowen, Richard and Golden, Sarah and Crist, Kathryn and Becker, Todd and Maddaloni, Massimo and Pascual, David W},
 issue = {18},
 journal = {Vaccine},
 month = {Apr},
 note = {The chemokine, lymphotactin (LTN), was tested as a molecular adjuvant using bicistronic DNA vaccines encoding the protective Yersinia capsular (F1) antigen and virulence antigen (V-Ag) as a F1-V fusion protein. The LTN-encoding F1-V or V-Ag vaccines were given by the intranasal (i.n.) or intramuscular (i.m.) routes, and although serum IgG and mucosal IgA antibodies (Abs) were induced, F1-Ag boosts were required for robust anti-F1-Ag Abs. Optimal efficacy against pneumonic plague was obtained in mice i.m.-, not i.n.-immunized with these DNA vaccines. These vaccines stimulated elevated Ag-specific Ab-forming cells and mixed Th cell responses, with Th17 cells markedly enhanced by i.m. immunization. These results show that LTN can be used as a molecular adjuvant to enhance protective immunity against plague., Vaccine, 28(18), pp.3219-3230; 2010},
 pages = {3219--3230},
 title = {A parenteral DNA vaccine protects against pneumonic plague.},
 volume = {28},
 year = {2010}
}