{"created":"2023-05-15T16:41:11.805400+00:00","id":15750,"links":{},"metadata":{"_buckets":{"deposit":"cb6699d9-1d37-4452-b126-22a65d6899f7"},"_deposit":{"created_by":2,"id":"15750","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"15750"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00015750","sets":["66:67"]},"author_link":["58733","58737","58732","58736","58740","58735","58734","58738","58739"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-04-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"18","bibliographicPageEnd":"3230","bibliographicPageStart":"3219","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Vaccine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The chemokine, lymphotactin (LTN), was tested as a molecular adjuvant using bicistronic DNA vaccines encoding the protective Yersinia capsular (F1) antigen and virulence antigen (V-Ag) as a F1-V fusion protein. The LTN-encoding F1-V or V-Ag vaccines were given by the intranasal (i.n.) or intramuscular (i.m.) routes, and although serum IgG and mucosal IgA antibodies (Abs) were induced, F1-Ag boosts were required for robust anti-F1-Ag Abs. Optimal efficacy against pneumonic plague was obtained in mice i.m.-, not i.n.-immunized with these DNA vaccines. These vaccines stimulated elevated Ag-specific Ab-forming cells and mixed Th cell responses, with Th17 cells markedly enhanced by i.m. immunization. These results show that LTN can be used as a molecular adjuvant to enhance protective immunity against plague.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Vaccine, 28(18), pp.3219-3230; 2010","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd."}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"20197132","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.vaccine.2010.02.022","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2010 Elsevier Ltd All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10491877","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0264410X","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13588745","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamanaka, Hitoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hoyt, Teri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yang, Xinghong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bowen, Richard"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Golden, Sarah"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Crist, Kathryn"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Becker, Todd"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maddaloni, Massimo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pascual, David W"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"Vaccine28_3219.pdf","filesize":[{"value":"810.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Vaccine28_3219.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/15750/files/Vaccine28_3219.pdf"},"version_id":"860bc568-0bcc-4508-94fc-d5840c476b48"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IgA","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphotactin","subitem_subject_scheme":"Other"},{"subitem_subject":"Mucosal","subitem_subject_scheme":"Other"},{"subitem_subject":"Pneumonic plague","subitem_subject_scheme":"Other"},{"subitem_subject":"Vaccines","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A parenteral DNA vaccine protects against pneumonic plague.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A parenteral DNA vaccine protects against pneumonic plague."}]},"item_type_id":"2","owner":"2","path":["67"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-30"},"publish_date":"2010-08-30","publish_status":"0","recid":"15750","relation_version_is_last":true,"title":["A parenteral DNA vaccine protects against pneumonic plague."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:23:35.906985+00:00"}