{"created":"2023-05-15T16:41:13.017184+00:00","id":15778,"links":{},"metadata":{"_buckets":{"deposit":"c13687d6-5e82-4af4-a246-9eb8341c1f03"},"_deposit":{"created_by":2,"id":"15778","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"15778"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00015778","sets":["10:11"]},"author_link":["58860","58861","58864","58859","58865","58858","58862","58857","58863"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-07-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"75","bibliographicPageStart":"69","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Acta histochemica et cytochemica"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Connexin43 (Cx43) is abundantly expressed in mammalian testes and implicated in the regulation of cell-to-cell interaction between germ cells and Sertoli cells, which is essential to the normal process of spermatogenesis. In the present study, we investigated the relation between Cx43 expression and the degree of spermatogenesis in infertile human testes. Immunohistochemical analysis of Cx43 was performed on testicular biopsies from 29 patients with azoospermia (n=23) and severe oligospermia (n=6), who gave informed consent to this experiment. The degree of testicular spermatogenesis was evaluated by Johnsen score. In the interstitium, immunostaining for Cx43 was localized to some focal parts of plasma membrane between neighboring Leydig cells. In seminiferous tubules with normal spermatogenesis, Cx43 expression was found between Sertoli cells and germ cells. However, Cx43 expression in maturation arrest was decreased and located mainly in the basal compartment of seminiferous tubules. Finally, there was a significant positive correlation between histological score of spermatogenesis and intensity of Cx43 (p=0.0294). These data suggest that the alteration of Cx43 expression may be involved in spermatogenic impairment, and that the communication between Sertoli cells and germ cells through Cx43 may be important for maturation of spermatogenesis.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta Histochemica et Cytochemica, 40(3), pp.69-75; 2007","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Society of Histochemistry and Cytochemistry"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"17653298","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1267/ahc.07001","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright ©2007 By the Japan Society of Histochemistry and Cytochemistry"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508022","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00445991","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13475800","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"日本組織細胞化学会"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuo, Yuzo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nomata, Koichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eguchi, Jiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aoki, Daiyu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Tomayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hishikawa, Yoshitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanetake, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibata, Yoshisada"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koji, Takehiko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"AHC40_69.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AHC40_69.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/15778/files/AHC40_69.pdf"},"version_id":"ec0a8ecb-f073-4b4e-9c74-590f7b7fb771"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"connexin43","subitem_subject_scheme":"Other"},{"subitem_subject":"Johnsen score","subitem_subject_scheme":"Other"},{"subitem_subject":"infertile human testes","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunohistochemical analysis of connexin43 expression in infertile human testes.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical analysis of connexin43 expression in infertile human testes."}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-31"},"publish_date":"2010-08-31","publish_status":"0","recid":"15778","relation_version_is_last":true,"title":["Immunohistochemical analysis of connexin43 expression in infertile human testes."],"weko_creator_id":"2","weko_shared_id":2},"updated":"2023-05-15T19:09:02.686728+00:00"}