@article{oai:nagasaki-u.repo.nii.ac.jp:00000158,
 author = {Togo, masaaki and Akazawa, Yuko and Akashi, Taro and Yamashita, Rika and Yoshitomi, Izumi and Ohba, Kazuo and Hashimoto, Satsuki and Iwashita, Hiroko and Kurogi, Tadafumi and Osada, Yukiko and Wada, Noriko and Imamura, Yoshifumi and Hashiguchi, Keiichi and Yamaguchi, Naoyuki and Kondo, Hisayoshi and Nakao, Kazuhiko},
 issue = {5},
 journal = {Acta medica Okayama},
 month = {Oct},
 note = {ndoscopic submucosal dissection (ESD) has become the first-line treatment for early gastric neoplasms; however, a subset of patients treated by this method develop aspiration pneumonia. We conducted a comprehensive prospective analysis of the factors contributing to post-ESD aspiration pneumonia in early gastric neoplasms in this study, with special focus on whether pre-treatment oral care can prevent aspiration pneumonia. Sixty-one patients who underwent ESD for gastric neoplasms were randomly assigned to the oral care or control groups. ESD was performed under deep sedation. Of 60 patients whose data were available for analysis, 5 (8.3%) experienced pneumonia confirmed either by chest radiography or computed tomography. Although no difference in the rate of pneumonia was found between 
the control and oral care groups, the post-oral care bacteria count was significantly higher in the saliva of patients who developed pneumonia compared to those without pneumonia. In addition, the presence of vascular brain diseases and the dose of meperidine were also significantly associated with the occurrence of pneumonia. These results suggest that the number of oral bacteria as well as pre-existing 
vascular brain diseases and high-dose narcotics can affect the incidence of post-ESD pneumonia., Acta medica Okayama, 74(5), pp.407-413; 2020},
 pages = {407--413},
 title = {Comprehensive Prospective Analysis of the Factors Contributing to Aspiration Pneumonia Following Endoscopic Submucosal Dissection in Patients with Early Gastric Neoplasms},
 volume = {74},
 year = {2020}
}